4cj7
From Proteopedia
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| - | {{STRUCTURE_4cj7| PDB=4cj7 | SCENE= }} | ||
| - | ===Structure of Crenactin, an archeal actin-like protein=== | ||
| - | == | + | ==Structure of Crenactin, an archeal actin-like protein== |
| - | [[4cj7]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CJ7 OCA]. | + | <StructureSection load='4cj7' size='340' side='right'caption='[[4cj7]], [[Resolution|resolution]] 3.20Å' scene=''> |
| - | [[ | + | == Structural highlights == |
| - | [[ | + | <table><tr><td colspan='2'>[[4cj7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrobaculum_calidifontis_JCM_11548 Pyrobaculum calidifontis JCM 11548]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CJ7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CJ7 FirstGlance]. <br> |
| - | [[ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2Å</td></tr> |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4cj7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cj7 OCA], [https://pdbe.org/4cj7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4cj7 RCSB], [https://www.ebi.ac.uk/pdbsum/4cj7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4cj7 ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: | + | == Function == |
| - | [[Category: | + | [https://www.uniprot.org/uniprot/CREN1_PYRCJ CREN1_PYRCJ] Forms the backbone of an actin-like archaeal cytoskeleton, which is involved in cell shape determination. Has ATPase activity. Shows highest activity towards ATP or GTP as nucleotide, and only residual activity on UTP, CTP and dNTPs.<ref>PMID:21414041</ref> |
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Polymerising proteins of the actin family are nearly ubiquitous. Crenactins, restricted to Crenarchaea, are more closely related to actin than bacterial MreB. Crenactins occur in gene clusters hinting at an unknown, but conserved function. We solved the crystal structure of crenactin at 3.2A resolution. The protein crystallises as a continuous right-handed helix with 8 subunits per complete turn, spanning 419A. The structure of crenactin shows several loops that are longer than in actin, but overall, crenactin is closely related to eukaryotic actin, with an RMSD of 1.6A. Crenactin filaments imaged by electron microscopy showed polymers with very similar helical parameters. | ||
| + | |||
| + | Crenactin from Pyrobaculum calidifontis is closely related to actin in structure and forms steep helical filaments.,Izore T, Duman R, Kureisaite-Ciziene D, Lowe J FEBS Lett. 2014 Jan 28. pii: S0014-5793(14)00058-1. doi:, 10.1016/j.febslet.2014.01.029. PMID:24486010<ref>PMID:24486010</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 4cj7" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Pyrobaculum calidifontis JCM 11548]] | ||
| + | [[Category: Duman RE]] | ||
| + | [[Category: Izore T]] | ||
| + | [[Category: Kureisaite-Ciziene D]] | ||
| + | [[Category: Lowe J]] | ||
Current revision
Structure of Crenactin, an archeal actin-like protein
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