3ai8

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{{STRUCTURE_3ai8| PDB=3ai8 | SCENE= }}
 
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===Cathepsin B in complex with the nitroxoline===
 
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==Function==
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==Cathepsin B in complex with the nitroxoline==
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[[http://www.uniprot.org/uniprot/CATB_HUMAN CATB_HUMAN]] Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis.
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<StructureSection load='3ai8' size='340' side='right'caption='[[3ai8]], [[Resolution|resolution]] 2.11&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[3ai8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AI8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3AI8 FirstGlance]. <br>
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[[3ai8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AI8 OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.11&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HNQ:5-NITROQUINOLIN-8-OL'>HNQ</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ai8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ai8 OCA], [https://pdbe.org/3ai8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ai8 RCSB], [https://www.ebi.ac.uk/pdbsum/3ai8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ai8 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CATB_HUMAN CATB_HUMAN] Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis.
==See Also==
==See Also==
*[[Cathepsin|Cathepsin]]
*[[Cathepsin|Cathepsin]]
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*[[Cathepsin 3D structures|Cathepsin 3D structures]]
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==Reference==
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__TOC__
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<ref group="xtra">PMID:021598397</ref><references group="xtra"/><references/>
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</StructureSection>
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[[Category: Cathepsin B]]
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[[Category: Homo sapiens]]
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[[Category: Human]]
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[[Category: Large Structures]]
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[[Category: Gobec, S.]]
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[[Category: Gobec S]]
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[[Category: Kos, J.]]
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[[Category: Kos J]]
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[[Category: Mirkovic, B.]]
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[[Category: Mirkovic B]]
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[[Category: Renko, M.]]
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[[Category: Renko M]]
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[[Category: Turk, D.]]
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[[Category: Turk D]]
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[[Category: 8-hydroxy-5-nitroquinoline]]
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[[Category: Cathepsin b]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Nitroxoline]]
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[[Category: Reversible inhibitor]]
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Current revision

Cathepsin B in complex with the nitroxoline

PDB ID 3ai8

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