3vzd

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{{STRUCTURE_3vzd| PDB=3vzd | SCENE= }}
 
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===Crystal structure of Sphingosine Kinase 1 with inhibitor and ADP===
 
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{{ABSTRACT_PUBMED_23602659}}
 
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==Function==
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==Crystal structure of Sphingosine Kinase 1 with inhibitor and ADP==
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[[http://www.uniprot.org/uniprot/SPHK1_HUMAN SPHK1_HUMAN]] Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro-sphingosine and to a lesser extent sphinganine, but not other lipids, such as D,L-threo-dihydrosphingosine, N,N-dimethylsphingosine, diacylglycerol, ceramide, or phosphatidylinositol.<ref>PMID:20577214</ref>
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<StructureSection load='3vzd' size='340' side='right'caption='[[3vzd]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3vzd]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VZD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3VZD FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=POP:PYROPHOSPHATE+2-'>POP</scene>, <scene name='pdbligand=UUL:4-{[4-(4-CHLOROPHENYL)-1,3-THIAZOL-2-YL]AMINO}PHENOL'>UUL</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3vzd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vzd OCA], [https://pdbe.org/3vzd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3vzd RCSB], [https://www.ebi.ac.uk/pdbsum/3vzd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3vzd ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SPHK1_HUMAN SPHK1_HUMAN] Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro-sphingosine and to a lesser extent sphinganine, but not other lipids, such as D,L-threo-dihydrosphingosine, N,N-dimethylsphingosine, diacylglycerol, ceramide, or phosphatidylinositol.<ref>PMID:20577214</ref>
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==About this Structure==
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==See Also==
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[[3vzd]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VZD OCA].
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*[[Sphingosine kinase|Sphingosine kinase]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:023602659</ref><references group="xtra"/><references/>
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__TOC__
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[[Category: Human]]
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</StructureSection>
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[[Category: Sphinganine kinase]]
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[[Category: Homo sapiens]]
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[[Category: Min, X.]]
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[[Category: Large Structures]]
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[[Category: Walker, N P.]]
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[[Category: Min X]]
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[[Category: Wang, Z.]]
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[[Category: Walker NP]]
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[[Category: Lipid kinase]]
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[[Category: Wang Z]]
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[[Category: Transferase-inhibitor complex]]
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Current revision

Crystal structure of Sphingosine Kinase 1 with inhibitor and ADP

PDB ID 3vzd

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