3w5q

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{{STRUCTURE_3w5q| PDB=3w5q | SCENE= }}
 
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===Crystal structure of complexes of vitamin D receptor ligand binding domain with lithocholic acid derivatives===
 
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{{ABSTRACT_PUBMED_23723390}}
 
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==Function==
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==Crystal structure of complexes of vitamin D receptor ligand binding domain with lithocholic acid derivatives==
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[[http://www.uniprot.org/uniprot/VDR_RAT VDR_RAT]] Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Regulates transcription of hormone sensitive genes via its association with the WINAC complex, a chromatin-remodeling complex. Recruited to promoters via its interaction with the WINAC complex subunit BAZ1B/WSTF, which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis.<ref>PMID:17227670</ref> [[http://www.uniprot.org/uniprot/MED1_HUMAN MED1_HUMAN]] Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.<ref>PMID:9653119</ref> <ref>PMID:10406464</ref> <ref>PMID:12218053</ref> <ref>PMID:12037571</ref> <ref>PMID:11867769</ref> <ref>PMID:12556447</ref> <ref>PMID:14636573</ref> <ref>PMID:15471764</ref> <ref>PMID:15340084</ref> <ref>PMID:15989967</ref> <ref>PMID:16574658</ref>
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<StructureSection load='3w5q' size='340' side='right'caption='[[3w5q]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[3w5q]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3W5Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3W5Q FirstGlance]. <br>
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[[3w5q]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3W5Q OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3KL:(5BETA,9BETA)-3-OXOCHOLAN-24-OIC+ACID'>3KL</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3w5q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3w5q OCA], [https://pdbe.org/3w5q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3w5q RCSB], [https://www.ebi.ac.uk/pdbsum/3w5q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3w5q ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/VDR_RAT VDR_RAT] Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Regulates transcription of hormone sensitive genes via its association with the WINAC complex, a chromatin-remodeling complex. Recruited to promoters via its interaction with the WINAC complex subunit BAZ1B/WSTF, which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis.<ref>PMID:17227670</ref>
==See Also==
==See Also==
*[[Sandbox vdr|Sandbox vdr]]
*[[Sandbox vdr|Sandbox vdr]]
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*[[Vitamin D receptor|Vitamin D receptor]]
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*[[Vitamin D receptor 3D structures|Vitamin D receptor 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:023723390</ref><references group="xtra"/><references/>
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__TOC__
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[[Category: Buffalo rat]]
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</StructureSection>
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[[Category: Ikura, T.]]
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[[Category: Homo sapiens]]
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[[Category: Ito, N.]]
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[[Category: Large Structures]]
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[[Category: Masuno, H.]]
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[[Category: Rattus norvegicus]]
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[[Category: Activator]]
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[[Category: Ikura T]]
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[[Category: Dna-binding]]
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[[Category: Ito N]]
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[[Category: Metal-binding]]
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[[Category: Masuno H]]
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[[Category: Nuclear receptor-agonist complex]]
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[[Category: Nucleus]]
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[[Category: Phosphoprotein]]
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[[Category: Receptor]]
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[[Category: Transcription]]
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[[Category: Transcription regulation]]
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[[Category: Zinc-finger]]
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Current revision

Crystal structure of complexes of vitamin D receptor ligand binding domain with lithocholic acid derivatives

PDB ID 3w5q

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