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4ayj

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{{STRUCTURE_4ayj| PDB=4ayj | SCENE= }}
 
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===Molecular structure of a metal-independent bacterial glycosyltransferase that catalyzes the synthesis of histo-blood group A antigen===
 
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{{ABSTRACT_PUBMED_23230506}}
 
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==About this Structure==
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==Molecular structure of a metal-independent bacterial glycosyltransferase that catalyzes the synthesis of histo-blood group A antigen==
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[[4ayj]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacteroides_fragilis_subsp._ovatus"_(eggerth_and_gagnon_1933)_holdeman_and_moore_1970 "bacteroides fragilis subsp. ovatus" (eggerth and gagnon 1933) holdeman and moore 1970]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AYJ OCA].
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<StructureSection load='4ayj' size='340' side='right'caption='[[4ayj]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4ayj]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacteroides_ovatus Bacteroides ovatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AYJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AYJ FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=PRD_900070:2-fucosyllactose'>PRD_900070</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ayj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ayj OCA], [https://pdbe.org/4ayj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ayj RCSB], [https://www.ebi.ac.uk/pdbsum/4ayj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ayj ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/A7LVT2_BACO1 A7LVT2_BACO1]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Histo-blood group antigens (HBGAs) are a source of antigenic variation between individuals that modulates resistance and susceptibility to pathogens and is a barrier to the spread of enveloped viruses. HBGAs are also produced by a few prokaryotes where they are synthesized by glycosyltransferases (GTs) related to human HBGA synthases. Here we report the first structure of a bacterial GT of this family, from an intestinal resident, Bacteroides ovatus. Unlike its mammalian homologues and other GTs with similar folds, this protein lacks a metal-binding Asp-X-Asp motif and is fully active in the absence of divalent metal ions, yet is strikingly similar in structure and in its interactions with substrates to structurally characterized mammalian metal-dependent mammalian homologues. This shows how an apparently major divergence in catalytic properties can be accommodated by minor structural adjustments and illustrates the structural underpinnings of horizontal transfer of a functional gene from prokaryotes to vertebrates.
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==See Also==
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Structure of a metal-independent bacterial glycosyltransferase that catalyzes the synthesis of histo-blood group A antigen.,Thiyagarajan N, Pham TT, Stinson B, Sundriyal A, Tumbale P, Lizotte-Waniewski M, Brew K, Acharya KR Sci Rep. 2012;2:940. doi: 10.1038/srep00940. Epub 2012 Dec 7. PMID:23230506<ref>PMID:23230506</ref>
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*[[Glycosyltransferase|Glycosyltransferase]]
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<ref group="xtra">PMID:023230506</ref><references group="xtra"/><references/>
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</div>
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[[Category: Glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase]]
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<div class="pdbe-citations 4ayj" style="background-color:#fffaf0;"></div>
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[[Category: Acharya, K R.]]
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[[Category: Brewb, K.]]
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==See Also==
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[[Category: Lizotte-Waniewskib, M.]]
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*[[Glycosyltransferase 3D structures|Glycosyltransferase 3D structures]]
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[[Category: Pham, T T.K.]]
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== References ==
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[[Category: Stinson, B.]]
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<references/>
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[[Category: Sundriyal, A.]]
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__TOC__
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[[Category: Thiyagarajan, N.]]
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</StructureSection>
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[[Category: Tumbale, P.]]
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[[Category: Bacteroides ovatus]]
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[[Category: Catalysis]]
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[[Category: Large Structures]]
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[[Category: Transferase]]
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[[Category: Acharya KR]]
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[[Category: Brewb K]]
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[[Category: Lizotte-Waniewskib M]]
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[[Category: Pham TTK]]
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[[Category: Stinson B]]
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[[Category: Sundriyal A]]
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[[Category: Thiyagarajan N]]
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[[Category: Tumbale P]]

Current revision

Molecular structure of a metal-independent bacterial glycosyltransferase that catalyzes the synthesis of histo-blood group A antigen

PDB ID 4ayj

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