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4nzh

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'''Unreleased structure'''
 
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The entry 4nzh is ON HOLD until Paper Publication
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==A. fumigatus flavin-dependent ornithine monooxygenase R279A mutant==
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<StructureSection load='4nzh' size='340' side='right'caption='[[4nzh]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4nzh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Aspergillus_fumigatus Aspergillus fumigatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NZH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NZH FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ORN:L-ORNITHINE'>ORN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4nzh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nzh OCA], [https://pdbe.org/4nzh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4nzh RCSB], [https://www.ebi.ac.uk/pdbsum/4nzh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4nzh ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SIDA_ASPFU SIDA_ASPFU] Catalyzes the conversion of L-ornithine to N(5)-hydroxyornithine, the first step in the biosynthesis of all hydroxamate-containing siderophores, such as the secreted triacetylfusarinine C (TAFC) involved in iron uptake and the intracellular iron storage compound desferriferricrocin (DFFC). Highly specific for its substrate, only hydrolyzing l-ornithine. Has preference for NADPH over NADH, NADPH playing a role in stabilization of the C4a-hydroperoxyflavin intermediate. Essential for virulence.<ref>PMID:15504822</ref> <ref>PMID:16113265</ref> <ref>PMID:20614882</ref> <ref>PMID:22465572</ref>
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Authors: Robinson, R., Franceschini, S., Sobrado, P.
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==See Also==
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*[[Monooxygenase 3D structures|Monooxygenase 3D structures]]
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Description: A. fumigatus flavin-dependent ornithine monooxygenase R279A mutant
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Aspergillus fumigatus]]
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[[Category: Large Structures]]
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[[Category: Franceschini S]]
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[[Category: Robinson R]]
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[[Category: Sobrado P]]

Current revision

A. fumigatus flavin-dependent ornithine monooxygenase R279A mutant

PDB ID 4nzh

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