4o2l
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of Mus musculus Rheb G63A mutant bound to GTP== | |
| + | <StructureSection load='4o2l' size='340' side='right'caption='[[4o2l]], [[Resolution|resolution]] 2.40Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4o2l]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O2L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4O2L FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4o2l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4o2l OCA], [https://pdbe.org/4o2l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4o2l RCSB], [https://www.ebi.ac.uk/pdbsum/4o2l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4o2l ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/RHEB_MOUSE RHEB_MOUSE] Stimulates the phosphorylation of S6K1 and EIF4EBP1 through activation of mTORC1 signaling. Activates the protein kinase activity of mTORC1. Has low intrinsic GTPase activity (By similarity). | ||
| - | + | ==See Also== | |
| - | + | *[[GTP-binding protein 3D structures|GTP-binding protein 3D structures]] | |
| - | + | *[[Stathmin-4 3D structures|Stathmin-4 3D structures]] | |
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Mus musculus]] | ||
| + | [[Category: Ho J]] | ||
| + | [[Category: Ikura M]] | ||
| + | [[Category: Ishiyama N]] | ||
| + | [[Category: Marshall CB]] | ||
| + | [[Category: Mazhab-Jafari MT]] | ||
| + | [[Category: Stambolic V]] | ||
Current revision
Structure of Mus musculus Rheb G63A mutant bound to GTP
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