3b3x
From Proteopedia
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| - | [[Image:3b3x.jpg|left|200px]]<br /><applet load="3b3x" size="350" color="white" frame="true" align="right" spinBox="true" | ||
| - | caption="3b3x, resolution 2.500Å" /> | ||
| - | '''Crystal structure of class A beta-lactamase of Bacillus licheniformis BS3 with aminocitrate'''<br /> | ||
| - | == | + | ==Crystal structure of class A beta-lactamase of Bacillus licheniformis BS3 with aminocitrate== |
| - | + | <StructureSection load='3b3x' size='340' side='right'caption='[[3b3x]], [[Resolution|resolution]] 2.50Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | [ | + | <table><tr><td colspan='2'>[[3b3x]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_licheniformis Bacillus licheniformis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B3X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3B3X FirstGlance]. <br> |
| - | [ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5Å</td></tr> |
| - | [ | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A33:2-(CARBOXYMETHYL)-D-ASPARTIC+ACID'>A33</scene></td></tr> |
| - | [ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3b3x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3b3x OCA], [https://pdbe.org/3b3x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3b3x RCSB], [https://www.ebi.ac.uk/pdbsum/3b3x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3b3x ProSAT]</span></td></tr> |
| - | [[ | + | </table> |
| - | [ | + | == Function == |
| - | [[ | + | [https://www.uniprot.org/uniprot/BLAC_BACLI BLAC_BACLI] |
| - | [ | + | == Evolutionary Conservation == |
| - | + | [[Image:Consurf_key_small.gif|200px|right]] | |
| - | + | Check<jmol> | |
| - | + | <jmolCheckbox> | |
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b3/3b3x_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3b3x ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The title compound 4 has been prepared in four steps from ethylglycinate in 63% overall yield. This amino analog of citric acid has been co-crystallized with the class A beta-lactamase BS3 of Bacillus licheniformis and the structure of the complex fully analyzed by X-ray diffraction. Tris-ethyl aminocitrate 3 and the free tris-acid 4 have been tested against a member beta-lactamase from all distinct subgroups. They are novel inhibitors of class A beta-lactamases, still modest but more potent than citrate and isocitrate. | ||
| - | + | 2-Aminopropane-1,2,3-tricarboxylic acid: Synthesis and co-crystallization with the class A beta-lactamase BS3 of Bacillus licheniformis.,Beck J, Sauvage E, Charlier P, Marchand-Brynaert J Bioorg Med Chem Lett. 2008 Jul 1;18(13):3764-8. Epub 2008 May 16. PMID:18515103<ref>PMID:18515103</ref> | |
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 3b3x" style="background-color:#fffaf0;"></div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Beta-lactamase 3D structures|Beta-lactamase 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Bacillus licheniformis]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Charlier P]] | ||
| + | [[Category: Herman R]] | ||
| + | [[Category: Kerff F]] | ||
| + | [[Category: Sauvage E]] | ||
Current revision
Crystal structure of class A beta-lactamase of Bacillus licheniformis BS3 with aminocitrate
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