4oi6

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(New page: '''Unreleased structure''' The entry 4oi6 is ON HOLD until Jan 18 2016 Authors: Lu, M., Yong-Liang Jiang, Wang, S., Cheng, W., Rong-Guang Zhang, Marie-Joelle Virolle, Chen, Y., Cong-Zha...)
Current revision (06:46, 17 October 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 4oi6 is ON HOLD until Jan 18 2016
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==Crystal structure analysis of nickel-bound form SCO4226 from Streptomyces coelicolor A3(2)==
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<StructureSection load='4oi6' size='340' side='right'caption='[[4oi6]], [[Resolution|resolution]] 2.04&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4oi6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_coelicolor_A3(2) Streptomyces coelicolor A3(2)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OI6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4OI6 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.04&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4oi6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oi6 OCA], [https://pdbe.org/4oi6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4oi6 RCSB], [https://www.ebi.ac.uk/pdbsum/4oi6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4oi6 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q9FCE4_STRCO Q9FCE4_STRCO]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The open reading frame SCO4226 of Streptomyces coelicolor A3(2) encodes an 82-residue hypothetical protein. Biochemical assays revealed that each SCO4226 dimer binds four nickel ions. To decipher the molecular function, we solved the crystal structures of SCO4226 in both apo- and nickel-bound (Ni-SCO4226) forms at 1.30 and 2.04 A resolution, respectively. Each subunit of SCO4226 dimer adopts a canonical ferredoxin-like fold with five beta-strands flanked by two alpha-helices. In the structure of Ni-SCO4226, four nickel ions are coordinated at the surface of the dimer. Further biochemical assays suggested that the binding of Ni2+ triggers the self-aggregation of SCO4226 in vitro. In addition, RT-qPCR assays demonstrated that the expression of SCO4226 gene in S. coelicolor is specifically up-regulated by the addition of Ni2+, but not other divalent ions such as Cu2+, Mn2+ or Co2+. All these results suggested that SCO4226 acts as a nickel binding protein, probably required for nickel sequestration and/or detoxification.
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Authors: Lu, M., Yong-Liang Jiang, Wang, S., Cheng, W., Rong-Guang Zhang, Marie-Joelle Virolle, Chen, Y., Cong-Zhao Zhou
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Streptomyces coelicolor SCO4226 Is a Nickel Binding Protein.,Lu M, Jiang YL, Wang S, Jin H, Zhang RG, Virolle MJ, Chen Y, Zhou CZ PLoS One. 2014 Oct 6;9(10):e109660. doi: 10.1371/journal.pone.0109660., eCollection 2014. PMID:25285530<ref>PMID:25285530</ref>
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Description: Crystal structure analysis of nickel-bound form SCO4226 from Streptomyces coelicolor A3(2)
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 4oi6" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Chen Y]]
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[[Category: Cheng W]]
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[[Category: Jiang YL]]
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[[Category: Lu M]]
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[[Category: Virolle MJ]]
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[[Category: Wang S]]
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[[Category: Zhang RG]]
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[[Category: Zhou CZ]]

Current revision

Crystal structure analysis of nickel-bound form SCO4226 from Streptomyces coelicolor A3(2)

PDB ID 4oi6

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