4man
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| - | {{STRUCTURE_4man| PDB=4man | SCENE= }} | ||
| - | ===Bcl_2-Navitoclax Analog (with Indole) Complex=== | ||
| - | {{ABSTRACT_PUBMED_23291630}} | ||
| - | == | + | ==Bcl_2-Navitoclax Analog (with Indole) Complex== |
| - | [[http://www.uniprot.org/uniprot/BCL2_HUMAN BCL2_HUMAN | + | <StructureSection load='4man' size='340' side='right'caption='[[4man]], [[Resolution|resolution]] 2.07Å' scene=''> |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4man]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4lxe 4lxe]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MAN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4MAN FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.07Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1Y1:4-[4-({4-CHLORO-3-[2-(DIMETHYLAMINO)ETHOXY]BIPHENYL-2-YL}METHYL)PIPERAZIN-1-YL]-2-(1H-INDOL-5-YLOXY)-N-({3-NITRO-4-[(TETRAHYDRO-2H-PYRAN-4-YLMETHYL)AMINO]PHENYL}SULFONYL)BENZAMIDE'>1Y1</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4man FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4man OCA], [https://pdbe.org/4man PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4man RCSB], [https://www.ebi.ac.uk/pdbsum/4man PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4man ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/BCL2_HUMAN BCL2_HUMAN] Note=A chromosomal aberration involving BCL2 has been found in chronic lymphatic leukemia. Translocation t(14;18)(q32;q21) with immunoglobulin gene regions. BCL2 mutations found in non-Hodgkin lymphomas carrying the chromosomal translocation could be attributed to the Ig somatic hypermutation mechanism resulting in nucleotide transitions. | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/BCL2_HUMAN BCL2_HUMAN] Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).<ref>PMID:18570871</ref> | ||
| - | == | + | ==See Also== |
| - | [[ | + | *[[B-cell lymphoma proteins 3D structures|B-cell lymphoma proteins 3D structures]] |
| - | + | == References == | |
| - | + | <references/> | |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
| - | == | + | [[Category: Homo sapiens]] |
| - | + | [[Category: Large Structures]] | |
| - | [[Category: | + | [[Category: Park CH]] |
| - | [[Category: | + | |
| - | [[Category: | + | |
Current revision
Bcl_2-Navitoclax Analog (with Indole) Complex
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