4l55
From Proteopedia
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| - | {{STRUCTURE_4l55| PDB=4l55 | SCENE= }} | ||
| - | ===X-ray structure of the adduct between bovine pancreatic ribonuclease and AziRu=== | ||
| - | {{ABSTRACT_PUBMED_24093479}} | ||
| - | == | + | ==X-ray structure of the adduct between bovine pancreatic ribonuclease and AziRu== |
| - | [[http://www.uniprot.org/uniprot/RNAS1_BOVIN RNAS1_BOVIN | + | <StructureSection load='4l55' size='340' side='right'caption='[[4l55]], [[Resolution|resolution]] 1.65Å' scene=''> |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4l55]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L55 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4L55 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.65Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=RU:RUTHENIUM+ION'>RU</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4l55 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l55 OCA], [https://pdbe.org/4l55 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4l55 RCSB], [https://www.ebi.ac.uk/pdbsum/4l55 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4l55 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/RNAS1_BOVIN RNAS1_BOVIN] Endonuclease that catalyzes the cleavage of RNA on the 3' side of pyrimidine nucleotides. Acts on single stranded and double stranded RNA.<ref>PMID:7479688</ref> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | A Raman-assisted crystallographic study on the adduct between AziRu, a Ru(III) complex with high antiproliferative activity, and RNase A is presented. The protein structure is not perturbed significantly by the Ru label. The metal coordinates to ND atoms of His105 or of His119 imidazole rings, losing all of its original ligands but retaining octahedral, although distorted, coordination geometry. The AziRu binding inactivates the enzyme, suggesting that its antitumor action can be exerted by a mechanism of competitive inhibition. | ||
| - | + | Investigating the ruthenium metalation of proteins: X-ray structure and Raman microspectroscopy of the complex between RNase A and AziRu.,Vergara A, Russo Krauss I, Montesarchio D, Paduano L, Merlino A Inorg Chem. 2013 Oct 7;52(19):10714-6. doi: 10.1021/ic401494v. Epub 2013 Sep 16. PMID:24093479<ref>PMID:24093479</ref> | |
| - | + | ||
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | < | + | </div> |
| + | <div class="pdbe-citations 4l55" style="background-color:#fffaf0;"></div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Ribonuclease 3D structures|Ribonuclease 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Bos taurus]] | [[Category: Bos taurus]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Merlino A]] |
| - | [[Category: | + | [[Category: Russo Krauss I]] |
| - | [[Category: Vergara | + | [[Category: Vergara A]] |
| - | + | ||
| - | + | ||
Current revision
X-ray structure of the adduct between bovine pancreatic ribonuclease and AziRu
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