3b93

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (11:28, 5 January 2022) (edit) (undo)
 
(10 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:3b93.jpg|left|200px]]<br /><applet load="3b93" size="350" color="white" frame="true" align="right" spinBox="true"
 
-
caption="3b93, resolution 2.2&Aring;" />
 
-
'''crystal structure of human GITRL'''<br />
 
-
==About this Structure==
+
==crystal structure of human GITRL==
-
3B93 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B93 OCA].
+
<StructureSection load='3b93' size='340' side='right'caption='[[3b93]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
-
[[Category: Homo sapiens]]
+
== Structural highlights ==
-
[[Category: Single protein]]
+
<table><tr><td colspan='2'>[[3b93]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B93 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3B93 FirstGlance]. <br>
-
[[Category: Song, X M.]]
+
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3b94|3b94]]</div></td></tr>
-
[[Category: Zhou, Z C.]]
+
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TNFSF18, AITRL, GITRL, TL6 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-
[[Category: asymmetric]]
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3b93 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3b93 OCA], [https://pdbe.org/3b93 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3b93 RCSB], [https://www.ebi.ac.uk/pdbsum/3b93 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3b93 ProSAT]</span></td></tr>
-
[[Category: c2 spacegroup]]
+
</table>
-
[[Category: cytokine]]
+
== Function ==
-
[[Category: glycoprotein]]
+
[[https://www.uniprot.org/uniprot/TNF18_HUMAN TNF18_HUMAN]] Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T-cell responses. Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B.<ref>PMID:17449724</ref> <ref>PMID:18040044</ref>
-
[[Category: membrane]]
+
== Evolutionary Conservation ==
-
[[Category: open trimer]]
+
[[Image:Consurf_key_small.gif|200px|right]]
-
[[Category: signal-anchor]]
+
Check<jmol>
-
[[Category: transmembrane]]
+
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b9/3b93_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3b93 ConSurf].
 +
<div style="clear:both"></div>
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 19:04:16 2008''
+
==See Also==
 +
*[[Tumor necrosis factor ligand superfamily 3D structures|Tumor necrosis factor ligand superfamily 3D structures]]
 +
*[[Tumor necrosis factor receptor 3D structures|Tumor necrosis factor receptor 3D structures]]
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Human]]
 +
[[Category: Large Structures]]
 +
[[Category: Song, X M]]
 +
[[Category: Zhou, Z C]]
 +
[[Category: Asymmetric]]
 +
[[Category: C2 spacegroup]]
 +
[[Category: Cytokine]]
 +
[[Category: Glycoprotein]]
 +
[[Category: Membrane]]
 +
[[Category: Open trimer]]
 +
[[Category: Signal-anchor]]
 +
[[Category: Transmembrane]]

Current revision

crystal structure of human GITRL

PDB ID 3b93

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3b93"
Personal tools