4hly

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{{STRUCTURE_4hly| PDB=4hly | SCENE= }}
 
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===The complex crystal structure of the DNA binding domain of vIRF-1 from the oncogenic KSHV with DNA===
 
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{{ABSTRACT_PUBMED_23435230}}
 
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==About this Structure==
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==The complex crystal structure of the DNA binding domain of vIRF-1 from the oncogenic KSHV with DNA==
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[[4hly]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Hhv-8 Hhv-8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HLY OCA].
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<StructureSection load='4hly' size='340' side='right'caption='[[4hly]], [[Resolution|resolution]] 1.48&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4hly]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_gammaherpesvirus_8 Human gammaherpesvirus 8] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HLY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HLY FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.48&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hly FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hly OCA], [https://pdbe.org/4hly PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hly RCSB], [https://www.ebi.ac.uk/pdbsum/4hly PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hly ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/VIRF1_HHV8P VIRF1_HHV8P] Plays a role in the inhibition of host innate response by repressing the expression of interferon-inducible genes and blocking host IRF1- and IRF3-mediated transcription. Blocks the interaction between host IRF3 and CREBBP. Regulates the host cellular metabolism by increasing glucose uptake, ATP production and lactate secretion through down-regulation of heterogeneous nuclear ribonuclear protein Q1/SYNCRIP. Mechanistically, induces ubiquitination and degradation of SYNCRIP through the ubiquitin-proteasome pathway by recruiting KLHL3/CUL3 ubiquitin ligase complex (PubMed:35538151). Disrupts host TP53 signaling pathway during viral infection by interacting with host USP7 and thereby decreasing the availability of USP7 for deubiquitinating and stabilizing TP53 (PubMed:26786098).<ref>PMID:11314014</ref> <ref>PMID:26786098</ref> <ref>PMID:35538151</ref> <ref>PMID:9365244</ref> <ref>PMID:9420276</ref>
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==Reference==
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==See Also==
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<ref group="xtra">PMID:023435230</ref><references group="xtra"/><references/>
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*[[Interferon regulatory factor|Interferon regulatory factor]]
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[[Category: Hhv-8]]
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== References ==
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[[Category: Hew, K.]]
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<references/>
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[[Category: Venkatachalam, R.]]
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__TOC__
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[[Category: Dna binding protein-dna complex]]
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</StructureSection>
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[[Category: Helix-turn-helix]]
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[[Category: Human gammaherpesvirus 8]]
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[[Category: Large Structures]]
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[[Category: Synthetic construct]]
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[[Category: Hew K]]
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[[Category: Venkatachalam R]]

Current revision

The complex crystal structure of the DNA binding domain of vIRF-1 from the oncogenic KSHV with DNA

PDB ID 4hly

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