4mgr

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (12:26, 1 March 2024) (edit) (undo)
 
(3 intermediate revisions not shown.)
Line 1: Line 1:
-
{{STRUCTURE_4mgr| PDB=4mgr | SCENE= }}
 
-
===The crystal structure of Bacillus subtilis GabR, an autorepressor and PLP- and GABA-dependent transcriptional activator of gabT===
 
-
{{ABSTRACT_PUBMED_24127574}}
 
-
==Function==
+
==The crystal structure of Bacillus subtilis GabR, an autorepressor and PLP- and GABA-dependent transcriptional activator of gabT==
-
[[http://www.uniprot.org/uniprot/GABR_BACSU GABR_BACSU]] Activates the transcription of the gabTD operon. Is also a repressor of its own expression, both in the presence and absence of GABA. Binds specifically to the DNA region overlapping the -35 region of the gabT promoter and the -10 and +1 regions of the gabR promoter. Principally regulates the utilization of gamma-aminobutyrate.<ref>PMID:12123465</ref> <ref>PMID:15223311</ref>
+
<StructureSection load='4mgr' size='340' side='right'caption='[[4mgr]], [[Resolution|resolution]] 2.55&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[4mgr]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MGR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4MGR FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.55&#8491;</td></tr>
 +
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4mgr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mgr OCA], [https://pdbe.org/4mgr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4mgr RCSB], [https://www.ebi.ac.uk/pdbsum/4mgr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4mgr ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/GABR_BACSU GABR_BACSU] Activates the transcription of the gabTD operon. Is also a repressor of its own expression, both in the presence and absence of GABA. Binds specifically to the DNA region overlapping the -35 region of the gabT promoter and the -10 and +1 regions of the gabR promoter. Principally regulates the utilization of gamma-aminobutyrate.<ref>PMID:12123465</ref> <ref>PMID:15223311</ref>
-
==About this Structure==
+
==See Also==
-
[[4mgr]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_globigii"_migula_1900 "bacillus globigii" migula 1900]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MGR OCA].
+
*[[Transcriptional activator 3D structures|Transcriptional activator 3D structures]]
-
 
+
== References ==
-
==Reference==
+
<references/>
-
<ref group="xtra">PMID:024127574</ref><references group="xtra"/><references/>
+
__TOC__
-
[[Category: Bacillus globigii migula 1900]]
+
</StructureSection>
-
[[Category: Bach, A.]]
+
[[Category: Bacillus subtilis]]
-
[[Category: Belitsky, B R.]]
+
[[Category: Large Structures]]
-
[[Category: Edayathumangalam, R.]]
+
[[Category: Bach A]]
-
[[Category: Garcia, R.]]
+
[[Category: Belitsky BR]]
-
[[Category: Hoang, Q Q.]]
+
[[Category: Edayathumangalam R]]
-
[[Category: Kreinbring, C A.]]
+
[[Category: Garcia R]]
-
[[Category: Liao, J.]]
+
[[Category: Hoang QQ]]
-
[[Category: Liu, D.]]
+
[[Category: Kreinbring CA]]
-
[[Category: Petsko, G A.]]
+
[[Category: Liao J]]
-
[[Category: Ringe, D.]]
+
[[Category: Liu D]]
-
[[Category: Stone, T.]]
+
[[Category: Petsko GA]]
-
[[Category: Terwilliger, T.]]
+
[[Category: Ringe D]]
-
[[Category: Wang, W.]]
+
[[Category: Stone T]]
-
[[Category: Wang, Y.]]
+
[[Category: Terwilliger T]]
-
[[Category: Wu, R.]]
+
[[Category: Wang W]]
-
[[Category: Dna binding]]
+
[[Category: Wang Y]]
-
[[Category: Plp binding]]
+
[[Category: Wu R]]
-
[[Category: Transcription regulator]]
+
-
[[Category: Type-i aminotransferase]]
+
-
[[Category: Winged helix turn helix]]
+

Current revision

The crystal structure of Bacillus subtilis GabR, an autorepressor and PLP- and GABA-dependent transcriptional activator of gabT

PDB ID 4mgr

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4mgr"
Personal tools