4inn

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{{STRUCTURE_4inn| PDB=4inn | SCENE= }}
 
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===Protein HP1028 from the human pathogen Helicobacter pylori belongs to the lipocalin family===
 
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{{ABSTRACT_PUBMED_23897462}}
 
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==About this Structure==
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==Protein HP1028 from the human pathogen Helicobacter pylori belongs to the lipocalin family==
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[[4inn]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Helicobacter_pylori_(strain_nctc11637) Helicobacter pylori (strain nctc11637)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4INN OCA].
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<StructureSection load='4inn' size='340' side='right'caption='[[4inn]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4inn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Helicobacter_pylori_NCTC_11637_=_CCUG_17874_=_ATCC_43504_=_JCM_12093 Helicobacter pylori NCTC 11637 = CCUG 17874 = ATCC 43504 = JCM 12093]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4INN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4INN FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=P33:3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL'>P33</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4inn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4inn OCA], [https://pdbe.org/4inn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4inn RCSB], [https://www.ebi.ac.uk/pdbsum/4inn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4inn ProSAT]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Helicobacter pylori is a bacterial pathogen that causes severe diseases, including gastritis, ulcers and gastric cancer. Although this bacterium has been extensively studied, the physiological functions of a large number of the proteins encoded by its genome are unknown. HP1028 is a protein that is relevant to colonization and to the survival of the bacterium in the stomach, but its function is not clearly understood. Bioinformatics studies suggest that HP1028 is a monomeric protein that is secreted in the H. pylori periplasm. The crystal structure of HP1028 has been determined at 2.6 A resolution using the SAD method. The three-dimensional structure of the protein reveals that it belongs to the lipocalin family, a group of proteins that bind and transport (often hydrophobic) small molecules. The structure of HP1028, together with the possible localization of the mature protein in the bacterial periplasm and the position of the hp1028 gene in the bacterial genome, point to a role in H. pylori chemotaxis.
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==Reference==
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Protein HP1028 from the human pathogen Helicobacter pylori belongs to the lipocalin family.,Barison N, Cendron L, Loconte V, Proctor EA, Dokholyan NV, Zanotti G Acta Crystallogr D Biol Crystallogr. 2013 Aug;69(Pt 8):1387-94. doi:, 10.1107/S0907444913008160. Epub 2013 Jul 13. PMID:23897462<ref>PMID:23897462</ref>
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<ref group="xtra">PMID:023897462</ref><references group="xtra"/><references/>
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[[Category: Barison, N.]]
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[Category: Cendron, L.]]
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</div>
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[[Category: Loconte, V.]]
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<div class="pdbe-citations 4inn" style="background-color:#fffaf0;"></div>
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[[Category: Zanotti, G.]]
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== References ==
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[[Category: Beta-barrel]]
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<references/>
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[[Category: Binding protein]]
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__TOC__
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[[Category: Lipocalins fold]]
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</StructureSection>
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[[Category: Transport protein]]
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[[Category: Helicobacter pylori NCTC 11637 = CCUG 17874 = ATCC 43504 = JCM 12093]]
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[[Category: Large Structures]]
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[[Category: Barison N]]
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[[Category: Cendron L]]
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[[Category: Loconte V]]
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[[Category: Zanotti G]]

Current revision

Protein HP1028 from the human pathogen Helicobacter pylori belongs to the lipocalin family

PDB ID 4inn

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