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4jsc

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{{STRUCTURE_4jsc| PDB=4jsc | SCENE= }}
 
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===The 2.5A crystal structure of humanized Xenopus MDM2 with RO5316533 - a pyrrolidine MDM2 inhibitor===
 
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{{ABSTRACT_PUBMED_23808545}}
 
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==Function==
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==The 2.5A crystal structure of humanized Xenopus MDM2 with RO5316533 - a pyrrolidine MDM2 inhibitor==
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[[http://www.uniprot.org/uniprot/MDM2_XENLA MDM2_XENLA]] E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degration by the proteasome (By similarity).
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<StructureSection load='4jsc' size='340' side='right'caption='[[4jsc]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4jsc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JSC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JSC FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1OY:(3S,4R,5S)-3-(3-CHLORO-2-FLUOROPHENYL)-4-(4-CHLORO-2-FLUOROPHENYL)-4-CYANO-N-[(3S)-3,4-DIHYDROXYBUTYL]-5-(2,2-DIMETHYLPROPYL)-D-PROLINAMIDE'>1OY</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4jsc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jsc OCA], [https://pdbe.org/4jsc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4jsc RCSB], [https://www.ebi.ac.uk/pdbsum/4jsc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4jsc ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MDM2_XENLA MDM2_XENLA] E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degration by the proteasome (By similarity).
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==About this Structure==
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==See Also==
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[[4jsc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/African_clawed_frog African clawed frog]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JSC OCA].
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*[[MDM2 3D structures|MDM2 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:023808545</ref><references group="xtra"/><references/>
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[[Category: Large Structures]]
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[[Category: African clawed frog]]
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[[Category: Xenopus laevis]]
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[[Category: Graves, B.]]
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[[Category: Graves B]]
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[[Category: Janson, C A.]]
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[[Category: Janson CA]]
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[[Category: Lukacs, C.]]
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[[Category: Lukacs C]]
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[[Category: E3 ubiquitin ligase]]
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[[Category: Ligase-antagonist complex]]
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[[Category: Ligase-ligase inhibitor complex]]
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[[Category: Nucleus]]
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[[Category: P53]]
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[[Category: Pyrrolidine]]
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Current revision

The 2.5A crystal structure of humanized Xenopus MDM2 with RO5316533 - a pyrrolidine MDM2 inhibitor

PDB ID 4jsc

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