3wqk

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(New page: '''Unreleased structure''' The entry 3wqk is ON HOLD Authors: Chan, H.C., Feng,X., Ko,T.P., Huang, C.H., Hu,Y., Zheng,Y., Bogue, S., Nakano, C., Hoshino, T., Zhang, L., Lv, P., Liu, W.,...)
Current revision (08:46, 20 March 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 3wqk is ON HOLD
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==Crystal structure of Rv3378c with PO4==
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<StructureSection load='3wqk' size='340' side='right'caption='[[3wqk]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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Authors: Chan, H.C., Feng,X., Ko,T.P., Huang, C.H., Hu,Y., Zheng,Y., Bogue, S., Nakano, C., Hoshino, T., Zhang, L., Lv, P., Liu, W., Crick, D., Liang, P. H., Wang, H. J., Oldfield, E, Guo, R. T.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3wqk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WQK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3WQK FirstGlance]. <br>
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Description: Crystal structure of Rv3378c with PO4
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3wqk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wqk OCA], [https://pdbe.org/3wqk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3wqk RCSB], [https://www.ebi.ac.uk/pdbsum/3wqk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3wqk ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TUBAT_MYCTU TUBAT_MYCTU] Tuberculosinyl transferase that catalyzes the condensation of adenosine and tuberculosinyl diphosphate (TbPP) to generate 1-tuberculosinyladenosine (1-TbAd), which acts as an antiacid that directly protects M.tuberculosis from acid pH and physically remodels M.tuberculosis phagolysosomes (PubMed:24516143, PubMed:31427817). In addition, acts as a phosphatase that catalyzes the diphosphate-removal from TbPP to produce both tuberculosinol (TOH) and isotuberculosinol (iso-TOH) (PubMed:21228491, PubMed:24475925). Has broad substrate specificity, and can also use the 3 labdadienyl diphosphates, copalyl diphosphate (CDP), ent-CDP and syn-CDP in vitro (PubMed:21290071).<ref>PMID:21228491</ref> <ref>PMID:21290071</ref> <ref>PMID:24475925</ref> <ref>PMID:24516143</ref> <ref>PMID:31427817</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Mycobacterium tuberculosis]]
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[[Category: Bogue S]]
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[[Category: Chan HC]]
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[[Category: Crick DC]]
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[[Category: Feng X]]
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[[Category: Guo RT]]
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[[Category: Hoshino T]]
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[[Category: Hu Y]]
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[[Category: Huang CH]]
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[[Category: Ko TP]]
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[[Category: Liang PH]]
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[[Category: Liu W]]
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[[Category: Lv P]]
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[[Category: Nakano C]]
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[[Category: Oldfield E]]
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[[Category: Wang AH]]
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[[Category: Zhang L]]
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[[Category: Zheng Y]]

Current revision

Crystal structure of Rv3378c with PO4

PDB ID 3wqk

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