3bhd

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[[Image:3bhd.gif|left|200px]]<br /><applet load="3bhd" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="3bhd, resolution 1.50&Aring;" />
 
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'''Crystal structure of human thiamine triphosphatase (THTPA)'''<br />
 
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==About this Structure==
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==Crystal structure of human thiamine triphosphatase (THTPA)==
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3BHD is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=SO4:'>SO4</scene>, <scene name='pdbligand=CL:'>CL</scene>, <scene name='pdbligand=NA:'>NA</scene>, <scene name='pdbligand=CIT:'>CIT</scene> and <scene name='pdbligand=GOL:'>GOL</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Thiamine-triphosphatase Thiamine-triphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.28 3.6.1.28] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BHD OCA].
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<StructureSection load='3bhd' size='340' side='right'caption='[[3bhd]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3bhd]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BHD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BHD FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3bhd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bhd OCA], [https://pdbe.org/3bhd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3bhd RCSB], [https://www.ebi.ac.uk/pdbsum/3bhd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3bhd ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/THTPA_HUMAN THTPA_HUMAN] Hydrolase highly specific for thiamine triphosphate (ThTP).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bh/3bhd_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3bhd ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Thiamine-triphosphatase]]
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[[Category: Arrowsmith CH]]
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[[Category: Arrowsmith, C H.]]
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[[Category: Berglund H]]
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[[Category: Berg, S Van den.]]
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[[Category: Busam RD]]
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[[Category: Berglund, H.]]
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[[Category: Collins R]]
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[[Category: Busam, R D.]]
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[[Category: Dahlgren LG]]
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[[Category: Collins, R.]]
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[[Category: Edwards AM]]
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[[Category: Dahlgren, L G.]]
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[[Category: Flodin S]]
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[[Category: Edwards, A M.]]
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[[Category: Flores A]]
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[[Category: Flodin, S.]]
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[[Category: Graslund S]]
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[[Category: Flores, A.]]
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[[Category: Hallberg BM]]
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[[Category: Graslund, S.]]
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[[Category: Hammarstrom M]]
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[[Category: Hallberg, B M.]]
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[[Category: Herman MD]]
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[[Category: Hammarstrom, M.]]
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[[Category: Johansson A]]
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[[Category: Herman, M D.]]
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[[Category: Johansson I]]
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[[Category: Johansson, A.]]
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[[Category: Kallas A]]
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[[Category: Johansson, I.]]
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[[Category: Karlberg T]]
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[[Category: Kallas, A.]]
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[[Category: Kotenyova T]]
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[[Category: Karlberg, T.]]
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[[Category: Lehtio L]]
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[[Category: Kotenyova, T.]]
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[[Category: Moche M]]
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[[Category: Lehtio, L.]]
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[[Category: Nilsson ME]]
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[[Category: Moche, M.]]
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[[Category: Nordlund P]]
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[[Category: Nilsson, M E.]]
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[[Category: Nyman T]]
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[[Category: Nordlund, P.]]
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[[Category: Persson C]]
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[[Category: Nyman, T.]]
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[[Category: Sagemark J]]
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[[Category: Persson, C.]]
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[[Category: Sundstrom M]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Svensson L]]
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[[Category: Sagemark, J.]]
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[[Category: Thorsell AG]]
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[[Category: Sundstrom, M.]]
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[[Category: Tresaugues L]]
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[[Category: Svensson, L.]]
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[[Category: Van den Berg S]]
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[[Category: Thorsell, A G.]]
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[[Category: Weigelt J]]
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[[Category: Tresaugues, L.]]
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[[Category: Welin M]]
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[[Category: Weigelt, J.]]
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[[Category: Welin, M.]]
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[[Category: CIT]]
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[[Category: CL]]
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[[Category: GOL]]
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[[Category: NA]]
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[[Category: SO4]]
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[[Category: acetylation]]
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[[Category: cyth domain]]
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[[Category: cytoplasm]]
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[[Category: hydrolase]]
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[[Category: phosphatase]]
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[[Category: sgc]]
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[[Category: structural genomics consortium]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 19:05:36 2008''
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Current revision

Crystal structure of human thiamine triphosphatase (THTPA)

PDB ID 3bhd

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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