4oo5

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'''Unreleased structure'''
 
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The entry 4oo5 is ON HOLD
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==Crystal Structure of S-nitrosated Human Thioredoxin Mutant==
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<StructureSection load='4oo5' size='340' side='right'caption='[[4oo5]], [[Resolution|resolution]] 1.54&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4oo5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OO5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4OO5 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.54&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SNC:S-NITROSO-CYSTEINE'>SNC</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4oo5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oo5 OCA], [https://pdbe.org/4oo5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4oo5 RCSB], [https://www.ebi.ac.uk/pdbsum/4oo5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4oo5 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/THIO_HUMAN THIO_HUMAN] Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA-binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity.<ref>PMID:2176490</ref> <ref>PMID:9108029</ref> <ref>PMID:11118054</ref> <ref>PMID:16408020</ref> <ref>PMID:17606900</ref> ADF augments the expression of the interleukin-2 receptor TAC (IL2R/P55).<ref>PMID:2176490</ref> <ref>PMID:9108029</ref> <ref>PMID:11118054</ref> <ref>PMID:16408020</ref> <ref>PMID:17606900</ref>
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Authors: The, J., Weichsel, A., Montfort, W.R.
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==See Also==
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*[[Thioredoxin 3D structures|Thioredoxin 3D structures]]
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Description: Crystal Structure of S-nitrosated Human Thioredoxin Mutant
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Montfort WR]]
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[[Category: The J]]
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[[Category: Weichsel A]]

Current revision

Crystal Structure of S-nitrosated Human Thioredoxin Mutant

PDB ID 4oo5

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