4n78

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{{STRUCTURE_4n78| PDB=4n78 | SCENE= }}
 
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===The WAVE Regulatory Complex Links Diverse Receptors to the Actin Cytoskeleton===
 
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{{ABSTRACT_PUBMED_24439376}}
 
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==Disease==
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==The WAVE Regulatory Complex Links Diverse Receptors to the Actin Cytoskeleton==
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[[http://www.uniprot.org/uniprot/CYFP1_HUMAN CYFP1_HUMAN]] Angelman syndrome.
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<StructureSection load='4n78' size='340' side='right'caption='[[4n78]], [[Resolution|resolution]] 2.43&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4n78]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N78 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4N78 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.43&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4n78 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n78 OCA], [https://pdbe.org/4n78 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4n78 RCSB], [https://www.ebi.ac.uk/pdbsum/4n78 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4n78 ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/CYFP1_HUMAN CYFP1_HUMAN] Angelman syndrome.
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== Function ==
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[https://www.uniprot.org/uniprot/CYFP1_HUMAN CYFP1_HUMAN] Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit is an adapter between EIF4E and FMR1. Promotes the translation repression activity of FMR1 in brain probably by mediating its association with EIF4E and mRNA (By similarity). Regulates formation of membrane ruffles and lamellipodia. Plays a role in axon outgrowth. Binds to F-actin but not to RNA. Part of the WAVE complex that regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1. Regulator of epithelial morphogenesis. May act as an invasion suppressor in cancers.<ref>PMID:9417078</ref> <ref>PMID:16260607</ref> <ref>PMID:19524508</ref> <ref>PMID:21107423</ref>
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==Function==
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==See Also==
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[[http://www.uniprot.org/uniprot/BRK1_HUMAN BRK1_HUMAN]] Involved in regulation of actin and microtubule organization. Part of a WAVE complex that activates the Arp2/3 complex.<ref>PMID:18560548</ref> [[http://www.uniprot.org/uniprot/CYFP1_HUMAN CYFP1_HUMAN]] Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit is an adapter between EIF4E and FMR1. Promotes the translation repression activity of FMR1 in brain probably by mediating its association with EIF4E and mRNA (By similarity). Regulates formation of membrane ruffles and lamellipodia. Plays a role in axon outgrowth. Binds to F-actin but not to RNA. Part of the WAVE complex that regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1. Regulator of epithelial morphogenesis. May act as an invasion suppressor in cancers.<ref>PMID:9417078</ref> <ref>PMID:16260607</ref> <ref>PMID:19524508</ref> <ref>PMID:21107423</ref> [[http://www.uniprot.org/uniprot/WASF1_HUMAN WASF1_HUMAN]] Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. [[http://www.uniprot.org/uniprot/NCKP1_HUMAN NCKP1_HUMAN]] Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1.
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*[[Wiskott-Aldrich syndrome protein|Wiskott-Aldrich syndrome protein]]
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== References ==
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==About this Structure==
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<references/>
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[[4n78]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N78 OCA].
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__TOC__
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</StructureSection>
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==Reference==
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[[Category: Homo sapiens]]
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<ref group="xtra">PMID:024439376</ref><references group="xtra"/><references/>
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[[Category: Large Structures]]
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[[Category: Chen, Z C.]]
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[[Category: Chen ZC]]
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[[Category: Actin dynamic]]
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[[Category: Protein binding]]
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Current revision

The WAVE Regulatory Complex Links Diverse Receptors to the Actin Cytoskeleton

PDB ID 4n78

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