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4o68
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| - | {{STRUCTURE_4o68| PDB=4o68 | SCENE= }} | ||
| - | ===Structure of human cyclic GMP-AMP synthase (cGAS)=== | ||
| - | == | + | ==Structure of human cyclic GMP-AMP synthase (cGAS)== |
| - | [[http://www.uniprot.org/uniprot/CGAS_HUMAN CGAS_HUMAN | + | <StructureSection load='4o68' size='340' side='right'caption='[[4o68]], [[Resolution|resolution]] 2.44Å' scene=''> |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4o68]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O68 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4O68 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.436Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4o68 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4o68 OCA], [https://pdbe.org/4o68 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4o68 RCSB], [https://www.ebi.ac.uk/pdbsum/4o68 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4o68 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/CGAS_HUMAN CGAS_HUMAN] Nucleotidyltransferase that catalyzes formation of cyclic GMP-AMP (cGAMP) from ATP and GTP and exhibits antiviral activity. Has antiviral activity by acting as a key cytosolic DNA sensor, the presence of DNA in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production.<ref>PMID:21478870</ref> <ref>PMID:23258413</ref> | ||
| - | == | + | ==See Also== |
| - | [[ | + | *[[Cyclic GMP-AMP synthase 3D synthase|Cyclic GMP-AMP synthase 3D synthase]] |
| - | + | == References == | |
| - | == | + | <references/> |
| - | <references | + | __TOC__ |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: Chen | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Chen Z]] |
| - | [[Category: Zhang | + | [[Category: Chen ZJ]] |
| - | [[Category: | + | [[Category: Zhang X]] |
| - | + | [[Category: Zhang XW]] | |
Current revision
Structure of human cyclic GMP-AMP synthase (cGAS)
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Categories: Homo sapiens | Large Structures | Chen Z | Chen ZJ | Zhang X | Zhang XW
