4o69

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{{STRUCTURE_4o69| PDB=4o69 | SCENE= }}
 
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===Human cyclic GMP-AMP synthase (cGAS) in complex with sulfate ion===
 
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==Function==
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==Human cyclic GMP-AMP synthase (cGAS) in complex with sulfate ion==
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[[http://www.uniprot.org/uniprot/CGAS_HUMAN CGAS_HUMAN]] Nucleotidyltransferase that catalyzes formation of cyclic GMP-AMP (cGAMP) from ATP and GTP and exhibits antiviral activity. Has antiviral activity by acting as a key cytosolic DNA sensor, the presence of DNA in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production.<ref>PMID:21478870</ref> <ref>PMID:23258413</ref>
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<StructureSection load='4o69' size='340' side='right'caption='[[4o69]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4o69]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O69 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4O69 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.252&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4o69 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4o69 OCA], [https://pdbe.org/4o69 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4o69 RCSB], [https://www.ebi.ac.uk/pdbsum/4o69 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4o69 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CGAS_HUMAN CGAS_HUMAN] Nucleotidyltransferase that catalyzes formation of cyclic GMP-AMP (cGAMP) from ATP and GTP and exhibits antiviral activity. Has antiviral activity by acting as a key cytosolic DNA sensor, the presence of DNA in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production.<ref>PMID:21478870</ref> <ref>PMID:23258413</ref>
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==About this Structure==
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==See Also==
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[[4o69]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O69 OCA].
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*[[Cyclic GMP-AMP synthase 3D synthase|Cyclic GMP-AMP synthase 3D synthase]]
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== References ==
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==Reference==
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<references/>
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<references group="xtra"/><references/>
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__TOC__
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[[Category: Cyclic GMP-AMP synthase]]
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</StructureSection>
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[[Category: Chen, Z.]]
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[[Category: Homo sapiens]]
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[[Category: Chen, Z J.]]
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[[Category: Large Structures]]
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[[Category: Zhang, X.]]
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[[Category: Chen Z]]
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[[Category: Zhang, X W.]]
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[[Category: Chen ZJ]]
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[[Category: Immune response]]
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[[Category: Zhang X]]
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[[Category: Transferase]]
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[[Category: Zhang XW]]

Current revision

Human cyclic GMP-AMP synthase (cGAS) in complex with sulfate ion

PDB ID 4o69

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