3l3u

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{{STRUCTURE_3l3u| PDB=3l3u | SCENE= }}
 
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===Crystal structure of the HIV-1 integrase core domain to 1.4A===
 
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{{ABSTRACT_PUBMED_20227411}}
 
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==About this Structure==
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==Crystal structure of the HIV-1 integrase core domain to 1.4A==
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[[3l3u]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/9hiv1 9hiv1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L3U OCA].
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<StructureSection load='3l3u' size='340' side='right'caption='[[3l3u]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3l3u]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L3U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3L3U FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3l3u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3l3u OCA], [https://pdbe.org/3l3u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3l3u RCSB], [https://www.ebi.ac.uk/pdbsum/3l3u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3l3u ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q72498_9HIV1 Q72498_9HIV1]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l3/3l3u_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3l3u ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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HIV integrase (IN) is an essential enzyme in HIV replication and an important target for drug design. IN has been shown to interact with a number of cellular and viral proteins during the integration process. Disruption of these important interactions could provide a mechanism for allosteric inhibition of IN. We present the highest resolution crystal structure of the IN core domain to date. We also present a crystal structure of the IN core domain in complex with sucrose which is bound at the dimer interface in a region that has previously been reported to bind integrase inhibitors.
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==See Also==
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Crystal structure of the HIV-1 integrase core domain in complex with sucrose reveals details of an allosteric inhibitory binding site.,Wielens J, Headey SJ, Jeevarajah D, Rhodes DI, Deadman J, Chalmers DK, Scanlon MJ, Parker MW FEBS Lett. 2010 Apr 16;584(8):1455-62. Epub 2010 Mar 16. PMID:20227411<ref>PMID:20227411</ref>
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*[[Retroviral Integrase|Retroviral Integrase]]
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<ref group="xtra">PMID:020227411</ref><references group="xtra"/><references/>
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</div>
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[[Category: 9hiv1]]
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<div class="pdbe-citations 3l3u" style="background-color:#fffaf0;"></div>
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[[Category: Chalmers, D K.]]
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[[Category: Parker, M W.]]
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==See Also==
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[[Category: Scanlon, M J.]]
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*[[Retroviral integrase 3D structures|Retroviral integrase 3D structures]]
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[[Category: Wielens, J.]]
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== References ==
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[[Category: Aid]]
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<references/>
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[[Category: Dna binding]]
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__TOC__
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[[Category: Dna integration]]
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</StructureSection>
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[[Category: Endonuclease]]
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[[Category: Human immunodeficiency virus 1]]
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[[Category: Integrase]]
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[[Category: Large Structures]]
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[[Category: Polynucleotidyl transferase]]
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[[Category: Chalmers DK]]
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[[Category: Viral protein]]
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[[Category: Parker MW]]
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[[Category: Scanlon MJ]]
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[[Category: Wielens J]]

Current revision

Crystal structure of the HIV-1 integrase core domain to 1.4A

PDB ID 3l3u

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