3jqo

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (05:55, 17 October 2024) (edit) (undo)
 
(6 intermediate revisions not shown.)
Line 1: Line 1:
-
{{STRUCTURE_3jqo| PDB=3jqo | SCENE= }}
 
-
===Crystal structure of the outer membrane complex of a type IV secretion system===
 
-
{{ABSTRACT_PUBMED_19946264}}
 
-
==About this Structure==
+
==Crystal structure of the outer membrane complex of a type IV secretion system==
-
[[3jqo]] is a 42 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JQO OCA].
+
<StructureSection load='3jqo' size='340' side='right'caption='[[3jqo]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[3jqo]] is a 42 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JQO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3JQO FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
 +
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LDA:LAURYL+DIMETHYLAMINE-N-OXIDE'>LDA</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3jqo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jqo OCA], [https://pdbe.org/3jqo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3jqo RCSB], [https://www.ebi.ac.uk/pdbsum/3jqo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3jqo ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/Q46705_ECOLX Q46705_ECOLX]
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jq/3jqo_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3jqo ConSurf].
 +
<div style="clear:both"></div>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
Type IV secretion systems are secretion nanomachines spanning the two membranes of Gram-negative bacteria. Three proteins, VirB7, VirB9 and VirB10, assemble into a 1.05 megadalton (MDa) core spanning the inner and outer membranes. This core consists of 14 copies of each of the proteins and forms two layers, the I and O layers, inserting in the inner and outer membrane, respectively. Here we present the crystal structure of a approximately 0.6 MDa outer-membrane complex containing the entire O layer. This structure is the largest determined for an outer-membrane channel and is unprecedented in being composed of three proteins. Unexpectedly, this structure identifies VirB10 as the outer-membrane channel with a unique hydrophobic double-helical transmembrane region. This structure establishes VirB10 as the only known protein crossing both membranes of Gram-negative bacteria. Comparison of the cryo-electron microscopy (cryo-EM) and crystallographic structures points to conformational changes regulating channel opening and closing.
-
==See Also==
+
Structure of the outer membrane complex of a type IV secretion system.,Chandran V, Fronzes R, Duquerroy S, Cronin N, Navaza J, Waksman G Nature. 2009 Dec 24;462(7276):1011-5. Epub 2009 Nov 29. PMID:19946264<ref>PMID:19946264</ref>
-
*[[Jmol/Visualizing large molecules|Jmol/Visualizing large molecules]]
+
-
==Reference==
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
<ref group="xtra">PMID:019946264</ref><references group="xtra"/><references/>
+
</div>
-
[[Category: Ecoli]]
+
<div class="pdbe-citations 3jqo" style="background-color:#fffaf0;"></div>
-
[[Category: Chandran, V.]]
+
== References ==
-
[[Category: Cronin, N.]]
+
<references/>
-
[[Category: Duquerroy, S.]]
+
__TOC__
-
[[Category: Fronzes, R.]]
+
</StructureSection>
-
[[Category: Navaza, J.]]
+
[[Category: Escherichia coli K-12]]
-
[[Category: Waksman, G.]]
+
[[Category: Large Structures]]
-
[[Category: Helical outer membrane tm]]
+
[[Category: Chandran V]]
-
[[Category: Outer membrane protein complex]]
+
[[Category: Cronin N]]
-
[[Category: Transport protein]]
+
[[Category: Duquerroy S]]
 +
[[Category: Fronzes R]]
 +
[[Category: Navaza J]]
 +
[[Category: Waksman G]]

Current revision

Crystal structure of the outer membrane complex of a type IV secretion system

PDB ID 3jqo

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3jqo"
Personal tools