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4oo4

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{{STRUCTURE_4oo4| PDB=4oo4 | SCENE= }}
 
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===Crystal Structure of Human Thioredoxin Mutant===
 
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{{ABSTRACT_PUBMED_20662007}}
 
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==Function==
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==Crystal Structure of Human Thioredoxin Mutant==
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[[http://www.uniprot.org/uniprot/THIO_HUMAN THIO_HUMAN]] Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA-binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity.<ref>PMID:2176490</ref> <ref>PMID:9108029</ref> <ref>PMID:11118054</ref> <ref>PMID:16408020</ref> <ref>PMID:17606900</ref> ADF augments the expression of the interleukin-2 receptor TAC (IL2R/P55).<ref>PMID:2176490</ref> <ref>PMID:9108029</ref> <ref>PMID:11118054</ref> <ref>PMID:16408020</ref> <ref>PMID:17606900</ref>
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<StructureSection load='4oo4' size='340' side='right'caption='[[4oo4]], [[Resolution|resolution]] 0.97&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4oo4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OO4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4OO4 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 0.97&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4oo4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oo4 OCA], [https://pdbe.org/4oo4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4oo4 RCSB], [https://www.ebi.ac.uk/pdbsum/4oo4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4oo4 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/THIO_HUMAN THIO_HUMAN] Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA-binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity.<ref>PMID:2176490</ref> <ref>PMID:9108029</ref> <ref>PMID:11118054</ref> <ref>PMID:16408020</ref> <ref>PMID:17606900</ref> ADF augments the expression of the interleukin-2 receptor TAC (IL2R/P55).<ref>PMID:2176490</ref> <ref>PMID:9108029</ref> <ref>PMID:11118054</ref> <ref>PMID:16408020</ref> <ref>PMID:17606900</ref>
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==About this Structure==
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==See Also==
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[[4oo4]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OO4 OCA].
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*[[Thioredoxin 3D structures|Thioredoxin 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:020662007</ref><references group="xtra"/><references/>
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__TOC__
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[[Category: Montfort, W R.]]
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</StructureSection>
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[[Category: The, J.]]
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[[Category: Homo sapiens]]
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[[Category: Weichsel, A.]]
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[[Category: Large Structures]]
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[[Category: Oxidoreductase]]
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[[Category: Montfort WR]]
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[[Category: S-nitrosation]]
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[[Category: The J]]
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[[Category: Weichsel A]]

Current revision

Crystal Structure of Human Thioredoxin Mutant

PDB ID 4oo4

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