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2mgu
From Proteopedia
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| - | {{STRUCTURE_2mgu| PDB=2mgu | SCENE= }} | ||
| - | ===Structure of the complex between calmodulin and the binding domain of HIV-1 matrix protein=== | ||
| - | == | + | ==Structure of the complex between calmodulin and the binding domain of HIV-1 matrix protein== |
| - | [[http://www.uniprot.org/uniprot/ | + | <StructureSection load='2mgu' size='340' side='right'caption='[[2mgu]]' scene=''> |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[2mgu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MGU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MGU FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mgu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mgu OCA], [https://pdbe.org/2mgu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mgu RCSB], [https://www.ebi.ac.uk/pdbsum/2mgu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mgu ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/CALM1_RAT CALM1_RAT] Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis. Mediates calcium-dependent inactivation of CACNA1C. Positively regulates calcium-activated potassium channel activity of KCNN2.[UniProtKB:P62158] | ||
| - | == | + | ==See Also== |
| - | [[ | + | *[[Calmodulin 3D structures|Calmodulin 3D structures]] |
| - | [[Category: | + | __TOC__ |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: | + | [[Category: Human immunodeficiency virus 1]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Rattus norvegicus]] |
| - | [[Category: | + | [[Category: Saad J]] |
| + | [[Category: Samal A]] | ||
| + | [[Category: Vlach J]] | ||
Current revision
Structure of the complex between calmodulin and the binding domain of HIV-1 matrix protein
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