4j4l

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{{STRUCTURE_4j4l| PDB=4j4l | SCENE= }}
 
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===Modular evolution and design of the protein binding interface===
 
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==Disease==
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==Modular evolution and design of the protein binding interface==
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[[http://www.uniprot.org/uniprot/IL6_HUMAN IL6_HUMAN]] Genetic variations in IL6 are associated with susceptibility to rheumatoid arthritis systemic juvenile (RASJ) [MIM:[http://omim.org/entry/604302 604302]]. An inflammatory articular disorder with systemic-onset beginning before the age of 16. It represents a subgroup of juvenile arthritis associated with severe extraarticular features and occasionally fatal complications. During active phases of the disorder, patients display a typical daily spiking fever, an evanescent macular rash, lymphadenopathy, hepatosplenomegaly, serositis, myalgia and arthritis. Note=A IL6 promoter polymorphism is associated with a lifetime risk of development of Kaposi sarcoma in HIV-infected men.
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<StructureSection load='4j4l' size='340' side='right'caption='[[4j4l]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4j4l]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Eptatretus_burgeri Eptatretus burgeri], [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [https://en.wikipedia.org/wiki/Listeria_monocytogenes Listeria monocytogenes] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J4L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4J4L FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4j4l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j4l OCA], [https://pdbe.org/4j4l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4j4l RCSB], [https://www.ebi.ac.uk/pdbsum/4j4l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4j4l ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q4G1L3_EPTBU Q4G1L3_EPTBU] [https://www.uniprot.org/uniprot/A4L9V2_LISMN A4L9V2_LISMN]
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==Function==
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==See Also==
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[[http://www.uniprot.org/uniprot/IL6_HUMAN IL6_HUMAN]] Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance.
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*[[Interleukin 3D structures|Interleukin 3D structures]]
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*[[Variable lymphocyte receptor 3D structures|Variable lymphocyte receptor 3D structures]]
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==About this Structure==
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__TOC__
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[[4j4l]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J4L OCA].
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</StructureSection>
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[[Category: Cheong, H K.]]
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[[Category: Eptatretus burgeri]]
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[[Category: Kim, H J.]]
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[[Category: Homo sapiens]]
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[[Category: Extracellular matrix]]
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[[Category: Large Structures]]
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[[Category: Il-6 binding]]
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[[Category: Listeria monocytogenes]]
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[[Category: Interleukin 6]]
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[[Category: Synthetic construct]]
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[[Category: Lrr]]
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[[Category: Cheong HK]]
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[[Category: Protein binding-cytokine complex]]
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[[Category: Kim HJ]]

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Modular evolution and design of the protein binding interface

PDB ID 4j4l

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