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Catechol O-methyltransferase

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<StructureSection load='3a7e' size='350' side='right' caption='Structure of human catechol O-methyltransferase complex with SAM and dinitrocatechol (PDB entry [[3a7e]])' scene=''>
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<StructureSection load='3a7e' size='350' side='right' caption='Structure of human catechol O-methyltransferase complex with SAM and dinitrocatechol (PDB entry [[3a7e]])' scene='55/551215/Cv/1'>
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__TOC__
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== Function ==
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'''Catechol O-methyltransferase''' (COMT) methylates catecholamines like dopamine, epinephrine and norepinephrine. The cofactor S-adenosyl-L-methionine (SAM) serves as the methyl donor in the reaction and is converted to to S-adenosyl-L-homocysteine (SAH) by the reaction. The Parkinson Disease drug levodopa is a substrate of COMT and COMT inhibitors like entacapone are used with levodopa in the disease treatment.
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'''Catechol O-methyltransferase''' (COMT) methylates catecholamines like dopamine, epinephrine and norepinephrine. The cofactor S-adenosyl-L-methionine (SAM) serves as the methyl donor in the reaction and is converted to to S-adenosyl-L-homocysteine (SAH) by the reaction.<ref>PMID:19111934</ref> For more details see [[Student Projects for UMass Chemistry 423 Spring 2012-6]].
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== Relevance ==
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The Parkinson Disease drug levodopa is a substrate of COMT and COMT inhibitors like entacapone are used with levodopa in the disease treatment.<ref>PMID:25559423</ref>
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==Structural highlights ==
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*<scene name='55/551215/Cv/4'>Active site of human catechol O-methyltransferase complex with SAM and dinitrocatechol</scene> (PDB entry [[3a7e]]). Water molecule is shown as red sphere.
== 3D Structures of catechol O-methyltransferase ==
== 3D Structures of catechol O-methyltransferase ==
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[[Catechol O-methyltransferase 3D structures]]
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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</StructureSection>
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[[2zlb]] – rCOMT – rat <BR />
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== References ==
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[[2zth]] – rCOMT + SAM <BR />
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<references/>
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[[3u81]] – rCOMT (mutant) + SAH<BR />
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[[1vid]] – rCOMT + SAM + dinitrocatechol <BR />
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[[1jr4]], [[3hvh]], [[3hvi]], [[3hvj]], [[3hvk]], [[3a7d]], [[3nw9]], [[3nwb]], [[3nwe]] – rCOMT + inhibitor<BR />
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[[3oe4]], [[3oe5]], [[3ozr]], [[3ozs]], [[3ozt]], [[3r6t]] – rCOMT (mutant) + inhibitor<BR />
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[[1h1d]], [[2cl5]], [[2zvj]], [[3s68]] – rCOMT + inhibitor + SAM<BR />
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[[2avd]] – hCOMT + SAM – human <BR />
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[[3bwm]], [[3a7e]] – hCOMT + SAM + dinitrocatechol <BR />
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[[3bwy]] – hCOMT (mutant) + SAM + dinitrocatechol <BR />
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[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Structure of human catechol O-methyltransferase complex with SAM and dinitrocatechol (PDB entry 3a7e)

Drag the structure with the mouse to rotate

References

  1. ↑ Tsuji E, Okazaki K, Isaji M, Takeda K. Crystal structures of the Apo and Holo form of rat catechol-O-methyltransferase. J Struct Biol. 2008 Dec 10. PMID:19111934 doi:S1047-8477(08)00293-1
  2. ↑ Muller T. Catechol-O-methyltransferase inhibitors in Parkinson's disease. Drugs. 2015 Feb;75(2):157-74. doi: 10.1007/s40265-014-0343-0. PMID:25559423 doi:http://dx.doi.org/10.1007/s40265-014-0343-0

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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