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3c5c

From Proteopedia

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[[Image:3c5c.jpg|left|200px]]<br /><applet load="3c5c" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="3c5c, resolution 1.850&Aring;" />
 
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'''Crystal structure of human Ras-like, family 12 protein in complex with GDP'''<br />
 
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==About this Structure==
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==Crystal structure of human Ras-like, family 12 protein in complex with GDP==
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3C5C is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=MG:'>MG</scene>, <scene name='pdbligand=GDP:'>GDP</scene> and <scene name='pdbligand=UNX:'>UNX</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Known structural/functional Sites: <scene name='pdbsite=AC1:Mg+Binding+Site+For+Residue+A+202'>AC1</scene>, <scene name='pdbsite=AC2:Mg+Binding+Site+For+Residue+B+202'>AC2</scene>, <scene name='pdbsite=AC3:Mg+Binding+Site+For+Residue+C+202'>AC3</scene>, <scene name='pdbsite=AC4:Mg+Binding+Site+For+Residue+D+202'>AC4</scene>, <scene name='pdbsite=AC5:Mg+Binding+Site+For+Residue+A+203'>AC5</scene>, <scene name='pdbsite=AC6:Mg+Binding+Site+For+Residue+C+203'>AC6</scene>, <scene name='pdbsite=AC7:Mg+Binding+Site+For+Residue+B+203'>AC7</scene>, <scene name='pdbsite=AC8:Gdp+Binding+Site+For+Residue+A+201'>AC8</scene>, <scene name='pdbsite=AC9:Gdp+Binding+Site+For+Residue+B+201'>AC9</scene>, <scene name='pdbsite=BC1:Gdp+Binding+Site+For+Residue+C+201'>BC1</scene>, <scene name='pdbsite=BC2:Gdp+Binding+Site+For+Residue+D+201'>BC2</scene>, <scene name='pdbsite=BC3:Unx+Binding+Site+For+Residue+A+204'>BC3</scene>, <scene name='pdbsite=BC4:Unx+Binding+Site+For+Residue+D+203'>BC4</scene> and <scene name='pdbsite=BC5:Unx+Binding+Site+For+Residue+C+204'>BC5</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C5C OCA].
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<StructureSection load='3c5c' size='340' side='right'caption='[[3c5c]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3c5c]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C5C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3C5C FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3c5c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3c5c OCA], [https://pdbe.org/3c5c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3c5c RCSB], [https://www.ebi.ac.uk/pdbsum/3c5c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3c5c ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RASLC_HUMAN RASLC_HUMAN]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c5/3c5c_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3c5c ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Arrowsmith, C H.]]
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[[Category: Arrowsmith CH]]
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[[Category: Bochkarev, A.]]
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[[Category: Bochkarev A]]
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[[Category: Bountra, C.]]
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[[Category: Bountra C]]
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[[Category: Edwards, A M.]]
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[[Category: Edwards AM]]
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[[Category: Loppnau, P.]]
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[[Category: Loppnau P]]
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[[Category: Park, H.]]
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[[Category: Park H]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Shen L]]
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[[Category: Shen, L.]]
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[[Category: Tempel W]]
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[[Category: Tempel, W.]]
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[[Category: Tong Y]]
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[[Category: Tong, Y.]]
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[[Category: Weigelt J]]
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[[Category: Weigelt, J.]]
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[[Category: GDP]]
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[[Category: MG]]
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[[Category: UNX]]
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[[Category: gdp]]
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[[Category: gtp-binding]]
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[[Category: gtpase]]
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[[Category: limited proteolysis]]
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[[Category: nucleotide-binding]]
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[[Category: ras]]
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[[Category: rasl12]]
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[[Category: sgc]]
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[[Category: signaling protein]]
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[[Category: structural genomics consortium]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 19:08:40 2008''
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Current revision

Crystal structure of human Ras-like, family 12 protein in complex with GDP

PDB ID 3c5c

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