1hc0
From Proteopedia
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| - | {{STRUCTURE_1hc0| PDB=1hc0 | SCENE= }} | ||
| - | ===structure of lysozyme with periodate=== | ||
| - | {{ABSTRACT_PUBMED_16131750}} | ||
| - | == | + | ==structure of lysozyme with periodate== |
| - | [[http://www.uniprot.org/uniprot/LYSC_CHICK LYSC_CHICK | + | <StructureSection load='1hc0' size='340' side='right'caption='[[1hc0]], [[Resolution|resolution]] 1.82Å' scene=''> |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[1hc0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HC0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HC0 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.82Å, 10 models</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1hc0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hc0 OCA], [https://pdbe.org/1hc0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1hc0 RCSB], [https://www.ebi.ac.uk/pdbsum/1hc0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hc0 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/LYSC_CHICK LYSC_CHICK] Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Has bacteriolytic activity against M.luteus.<ref>PMID:22044478</ref> | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hc/1hc0_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1hc0 ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The structure of tetragonal hen egg-white lysozyme soaked in a periodate solution has been determined to a resolution of 1.8 A. Four high-occupancy periodate positions have been identified on the basis of the anomalous signal of the I atoms. The four periodates exhibit a regular rectangular arrangement on the surface of the lysozyme molecule. No similar regular arrangement was found either in lysozyme crystals soaked in other heavy-atom anions or in other structures from the Protein Data Bank. Depending on their position on the surface of the protein, the periodate ions deviate to a varying extent from ideal octahedral geometry. | ||
| - | + | Regular arrangement of periodates bound to lysozyme.,Ondracek J, Weiss MS, Brynda J, Fiala J, Jursik F, Rezacova P, Jenner LB, Sedlacek J Acta Crystallogr D Biol Crystallogr. 2005 Sep;61(Pt 9):1181-9. Epub 2005, Aug 16. PMID:16131750<ref>PMID:16131750</ref> | |
| - | + | ||
| - | == | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
| - | + | </div> | |
| + | <div class="pdbe-citations 1hc0" style="background-color:#fffaf0;"></div> | ||
| - | == | + | ==See Also== |
| - | + | *[[Lysozyme 3D structures|Lysozyme 3D structures]] | |
| - | [[Category: | + | == References == |
| - | [[Category: | + | <references/> |
| - | [[Category: Brynda | + | __TOC__ |
| - | [[Category: Jursik | + | </StructureSection> |
| - | [[Category: Ondracek | + | [[Category: Gallus gallus]] |
| - | [[Category: Rezacova | + | [[Category: Large Structures]] |
| - | [[Category: Sedlacek | + | [[Category: Brynda J]] |
| - | + | [[Category: Jursik F]] | |
| - | + | [[Category: Ondracek J]] | |
| - | + | [[Category: Rezacova P]] | |
| + | [[Category: Sedlacek J]] | ||
Current revision
structure of lysozyme with periodate
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