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4leg
From Proteopedia
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| - | {{STRUCTURE_4leg| PDB=4leg | SCENE= }}
| + | #REDIRECT [[5j94]] This PDB entry is obsolete and replaced by 5j94 |
| - | ===Human cathepsin K mutant C25S in complex with an allosteric modifier===
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| - | {{ABSTRACT_PUBMED_24518821}}
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| - | ==Disease==
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| - | [[http://www.uniprot.org/uniprot/CATK_HUMAN CATK_HUMAN]] Defects in CTSK are the cause of pycnodysostosis (PKND) [MIM:[http://omim.org/entry/265800 265800]]. PKND is an autosomal recessive osteochondrodysplasia characterized by osteosclerosis and short stature.<ref>PMID:8703060</ref> <ref>PMID:9529353</ref> <ref>PMID:10491211</ref> <ref>PMID:10878663</ref> | + | |
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| - | ==Function==
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| - | [[http://www.uniprot.org/uniprot/CATK_HUMAN CATK_HUMAN]] Closely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation.
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| - | ==About this Structure==
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| - | [[4leg]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LEG OCA].
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| - | ==See Also==
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| - | *[[Cathepsin|Cathepsin]]
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| - | ==Reference==
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| - | <ref group="xtra">PMID:024518821</ref><references group="xtra"/><references/>
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| - | [[Category: Cathepsin K]]
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| - | [[Category: Baici, A.]]
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| - | [[Category: Korenc, M.]]
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| - | [[Category: Lenarcic, B.]]
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| - | [[Category: Novinec, M.]]
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| - | [[Category: Hydrolase]]
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| - | [[Category: Papain-like cysteine peptidase]]
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| - | [[Category: Protease]]
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| - | [[Category: Thiol protease]]
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Current revision
- REDIRECT 5j94 This PDB entry is obsolete and replaced by 5j94
