4noj

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{{STRUCTURE_4noj| PDB=4noj | SCENE= }}
 
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===Crystal structure of the mature form of asparaginyl endopeptidase (AEP)/Legumain activated at pH 3.5===
 
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{{ABSTRACT_PUBMED_24407422}}
 
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==Function==
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==Crystal structure of the mature form of asparaginyl endopeptidase (AEP)/Legumain activated at pH 3.5==
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[[http://www.uniprot.org/uniprot/LGMN_MOUSE LGMN_MOUSE]] Has a strict specificity for hydrolysis of asparaginyl bonds. Can also cleave aspartyl bonds slowly, especially under acidic conditions. May be involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system. Required for normal lysosomal protein degradation in renal proximal tubules. Required for normal degradation of internalized EGFR. Plays a role in the regulation of cell proliferation via its role in EGFR degradation.<ref>PMID:9742219</ref> <ref>PMID:17350006</ref> <ref>PMID:21292981</ref>
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<StructureSection load='4noj' size='340' side='right'caption='[[4noj]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[4noj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NOJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NOJ FirstGlance]. <br>
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[[4noj]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NOJ OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4noj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4noj OCA], [https://pdbe.org/4noj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4noj RCSB], [https://www.ebi.ac.uk/pdbsum/4noj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4noj ProSAT]</span></td></tr>
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==Reference==
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</table>
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<ref group="xtra">PMID:024407422</ref><references group="xtra"/><references/>
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== Function ==
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[[Category: Legumain]]
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[https://www.uniprot.org/uniprot/LGMN_MOUSE LGMN_MOUSE] Has a strict specificity for hydrolysis of asparaginyl bonds. Can also cleave aspartyl bonds slowly, especially under acidic conditions. May be involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system. Required for normal lysosomal protein degradation in renal proximal tubules. Required for normal degradation of internalized EGFR. Plays a role in the regulation of cell proliferation via its role in EGFR degradation.<ref>PMID:9742219</ref> <ref>PMID:17350006</ref> <ref>PMID:21292981</ref>
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[[Category: Ding, W.]]
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== References ==
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[[Category: Hua, T.]]
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<references/>
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[[Category: Jiao, L.]]
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__TOC__
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[[Category: Liu, Z J.]]
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</StructureSection>
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[[Category: Ni, X.]]
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[[Category: Large Structures]]
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[[Category: Ouyang, S.]]
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[[Category: Mus musculus]]
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[[Category: Qu, L.]]
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[[Category: Ding W]]
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[[Category: Ru, H.]]
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[[Category: Hua T]]
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[[Category: Shaw, N.]]
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[[Category: Jiao L]]
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[[Category: Zhao, L.]]
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[[Category: Liu ZJ]]
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[[Category: Asparaginyl endopeptidase]]
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[[Category: Ni X]]
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[[Category: Extracellular]]
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[[Category: Ouyang S]]
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[[Category: Hydrolase]]
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[[Category: Qu L]]
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[[Category: New fold]]
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[[Category: Ru H]]
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[[Category: Substrate]]
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[[Category: Shaw N]]
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[[Category: Zhao L]]

Current revision

Crystal structure of the mature form of asparaginyl endopeptidase (AEP)/Legumain activated at pH 3.5

PDB ID 4noj

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OCA

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