4n9e

{{STRUCTURE_4n9e| PDB=4n9e | SCENE= }}

===Fragment-based Design of 3-Aminopyridine-derived Amides as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (NAMPT)===

{{ABSTRACT_PUBMED_24433859}}

==Function==

[[http://www.uniprot.org/uniprot/NAMPT_HUMAN NAMPT_HUMAN]] Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway (By similarity).

==About this Structure==

[[4n9e]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N9E OCA].

 

<ref group="xtra">PMID:024433859</ref><references group="xtra"/><references/>

[[Category: Nicotinamide phosphoribosyltransferase]]

[[Category: Baumeister, T.]]

[[Category: Bravo, B.]]

[[Category: Brien, T O.]]

[[Category: Dragovich, P S.]]

[[Category: Giannetti, A M.]]

[[Category: Ho, Y.]]

[[Category: Hua, R.]]

[[Category: Li, G.]]

[[Category: Liang, X.]]

[[Category: Oh, A.]]

[[Category: Skelton, N J.]]

[[Category: Wang, C.]]

[[Category: Wang, W.]]

[[Category: Wang, Y.]]

[[Category: Xiao, Y.]]

[[Category: Yuen, P.]]

[[Category: Zak, M.]]

[[Category: Zhao, G.]]

[[Category: Zhao, Q.]]

[[Category: Zheng, X.]]

[[Category: Transferase-transferase inhibitor complex]]