4n5x

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{{STRUCTURE_4n5x| PDB=4n5x | SCENE= }}
 
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===Crystal structure of N-terminal calmodulin-like Calcium sensor of human mitochondrial ATP-Mg/Pi carrier SCaMC1===
 
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{{ABSTRACT_PUBMED_24332718}}
 
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==Function==
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==Crystal structure of N-terminal calmodulin-like Calcium sensor of human mitochondrial ATP-Mg/Pi carrier SCaMC1==
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[[http://www.uniprot.org/uniprot/SCMC1_HUMAN SCMC1_HUMAN]] Calcium-dependent mitochondrial solute carrier. Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial inner membrane. May act as a ATP-Mg/Pi exchanger that mediates the transport of Mg-ATP in exchange for phosphate, catalyzing the net uptake or efflux of adenine nucleotides into or from the mitochondria.<ref>PMID:15123600</ref>
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<StructureSection load='4n5x' size='340' side='right'caption='[[4n5x]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4n5x]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N5X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4N5X FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4n5x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n5x OCA], [https://pdbe.org/4n5x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4n5x RCSB], [https://www.ebi.ac.uk/pdbsum/4n5x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4n5x ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SCMC1_HUMAN SCMC1_HUMAN] Calcium-dependent mitochondrial solute carrier. Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial inner membrane. May act as a ATP-Mg/Pi exchanger that mediates the transport of Mg-ATP in exchange for phosphate, catalyzing the net uptake or efflux of adenine nucleotides into or from the mitochondria.<ref>PMID:15123600</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The mitochondrial carriers play essential roles in energy metabolism. The short Ca(2+)-binding mitochondrial carrier (SCaMC) transports ATP-Mg in exchange for Pi and is important for activities that depend on adenine nucleotides. SCaMC adopts, in addition to the transmembrane domain (TMD) that transports solutes, an extramembrane N-terminal domain (NTD) that regulates solute transport in a Ca(2+)-dependent manner. Crystal structure of the Ca(2+)-bound NTD reveals a compact architecture in which the functional EF hands are sequestered by an endogenous helical segment. Nuclear magnetic resonance (NMR) relaxation rates indicated that removal of Ca(2+) from NTD results in a major conformational switch from the rigid and compact Ca(2+)-bound state to the dynamic and loose apo state. Finally, we showed using surface plasmon resonance and NMR titration experiments that free apo NTDs could specifically interact with liposome-incorporated TMD, but that Ca(2+) binding drastically weakened the interaction. Our results together provide a molecular explanation for Ca(2+)-dependent ATP-Mg flux in mitochondria.
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==About this Structure==
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A Self-Sequestered Calmodulin-like Ca(2+) Sensor of Mitochondrial SCaMC Carrier and Its Implication to Ca(2+)-Dependent ATP-Mg/Pi Transport.,Yang Q, Bruschweiler S, Chou JJ Structure. 2014 Feb 4;22(2):209-17. doi: 10.1016/j.str.2013.10.018. Epub 2013 Dec, 12. PMID:24332718<ref>PMID:24332718</ref>
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[[4n5x]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N5X OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<ref group="xtra">PMID:024332718</ref><references group="xtra"/><references/>
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</div>
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[[Category: Bruschweiler, S.]]
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<div class="pdbe-citations 4n5x" style="background-color:#fffaf0;"></div>
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[[Category: Chou, J.]]
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== References ==
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[[Category: Yang, Q.]]
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<references/>
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[[Category: Calcium sensor]]
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__TOC__
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[[Category: Calcium-binding protein]]
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</StructureSection>
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[[Category: Calmodulin]]
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[[Category: Homo sapiens]]
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[[Category: Mitochondrial inner membrane]]
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[[Category: Large Structures]]
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[[Category: Bruschweiler S]]
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[[Category: Chou J]]
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[[Category: Yang Q]]

Current revision

Crystal structure of N-terminal calmodulin-like Calcium sensor of human mitochondrial ATP-Mg/Pi carrier SCaMC1

PDB ID 4n5x

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