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4m61
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| - | {{STRUCTURE_4m61| PDB=4m61 | SCENE= }} | ||
| - | ===Crystal structure of unliganded anti-DNA Fab A52=== | ||
| - | {{ABSTRACT_PUBMED_24449198}} | ||
| - | == | + | ==Crystal structure of unliganded anti-DNA Fab A52== |
| - | [[4m61]] is a 4 chain structure with sequence from [ | + | <StructureSection load='4m61' size='340' side='right'caption='[[4m61]], [[Resolution|resolution]] 1.62Å' scene=''> |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4m61]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M61 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4M61 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.62Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4m61 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m61 OCA], [https://pdbe.org/4m61 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4m61 RCSB], [https://www.ebi.ac.uk/pdbsum/4m61 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4m61 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | A52 is a murine monoclonal antibody isolated from autoimmune New Zealand Black/New Zealand White F1 mice that recognizes single and double stranded DNA. This mouse strain spontaneously develops systemic lupus erythematosus-like symptoms and has served as a model for that disease for many years. The 1.62 A crystal structure of the A52 Fab fragment reveals an H3 complementarity determining region with four closely spaced arginine residues, creating a positively charged surface to accommodate bound DNA. Proteins 2014. (c) 2014 Wiley Periodicals, Inc. | ||
| - | + | Crystal structure determination of anti-DNA Fab A52.,Stanfield RL, Eilat D Proteins. 2014 Jan 22. doi: 10.1002/prot.24514. PMID:24449198<ref>PMID:24449198</ref> | |
| - | <ref | + | |
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 4m61" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
| - | [[Category: Eilat | + | [[Category: Eilat D]] |
| - | [[Category: Stanfield | + | [[Category: Stanfield RL]] |
| - | [[Category: Wilson | + | [[Category: Wilson IA]] |
| - | + | ||
| - | + | ||
Current revision
Crystal structure of unliganded anti-DNA Fab A52
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