4azm

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{{STRUCTURE_4azm| PDB=4azm | SCENE= }}
 
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===Human epidermal fatty acid-binding protein (FABP5) in complex with the inhibitor BMS-309413===
 
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{{ABSTRACT_PUBMED_24531463}}
 
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==Function==
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==Human epidermal fatty acid-binding protein (FABP5) in complex with the inhibitor BMS-309413==
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[[http://www.uniprot.org/uniprot/FABP5_HUMAN FABP5_HUMAN]] High specificity for fatty acids. Highest affinity for C18 chain length. Decreasing the chain length or introducing double bonds reduces the affinity. May be involved in keratinocyte differentiation.
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<StructureSection load='4azm' size='340' side='right'caption='[[4azm]], [[Resolution|resolution]] 2.75&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4azm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AZM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AZM FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.75&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=T4B:((2-(5-ETHYL-3,4-DIPHENYL-1H-PYRAZOL-1-YL)-3-BIPHENYLYL)OXY)ACETIC+ACID'>T4B</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4azm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4azm OCA], [https://pdbe.org/4azm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4azm RCSB], [https://www.ebi.ac.uk/pdbsum/4azm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4azm ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/FABP5_HUMAN FABP5_HUMAN] High specificity for fatty acids. Highest affinity for C18 chain length. Decreasing the chain length or introducing double bonds reduces the affinity. May be involved in keratinocyte differentiation.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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In addition to binding intracellular fatty acids, fatty-acid-binding proteins (FABPs) have recently been reported to also transport the endocannabinoids anandamide (AEA) and 2-arachidonoylglycerol (2-AG), arachidonic acid derivatives that function as neurotransmitters and mediate a diverse set of physiological and psychological processes. To understand how the endocannabinoids bind to FABPs, the crystal structures of FABP5 in complex with AEA, 2-AG and the inhibitor BMS-309403 were determined. These ligands are shown to interact primarily with the substrate-binding pocket via hydrophobic interactions as well as a common hydrogen bond to the Tyr131 residue. This work advances our understanding of FABP5-endocannabinoid interactions and may be useful for future efforts in the development of small-molecule inhibitors to raise endocannabinoid levels.
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==About this Structure==
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Crystallographic study of FABP5 as an intracellular endocannabinoid transporter.,Sanson B, Wang T, Sun J, Wang L, Kaczocha M, Ojima I, Deutsch D, Li H Acta Crystallogr D Biol Crystallogr. 2014 Feb;70(Pt 2):290-8. doi:, 10.1107/S1399004713026795. Epub 2014 Jan 29. PMID:24531463<ref>PMID:24531463</ref>
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[[4azm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AZM OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<ref group="xtra">PMID:024531463</ref><references group="xtra"/><references/>
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</div>
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[[Category: Human]]
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<div class="pdbe-citations 4azm" style="background-color:#fffaf0;"></div>
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[[Category: Deutsch, D.]]
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[[Category: Kaczocha, M.]]
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==See Also==
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[[Category: Li, H.]]
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*[[Fatty acid-binding protein 3D structures|Fatty acid-binding protein 3D structures]]
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[[Category: Ojima, I.]]
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== References ==
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[[Category: Sanson, B.]]
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<references/>
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[[Category: Sun, J.]]
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__TOC__
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[[Category: Wang, T.]]
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</StructureSection>
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[[Category: Beta-barrel]]
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[[Category: Homo sapiens]]
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[[Category: Beta-clamshell]]
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[[Category: Large Structures]]
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[[Category: Domain swapping]]
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[[Category: Deutsch D]]
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[[Category: Endocannabinoid]]
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[[Category: Kaczocha M]]
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[[Category: Lipid binding protein]]
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[[Category: Li H]]
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[[Category: Lipid carrier protein]]
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[[Category: Ojima I]]
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[[Category: Sanson B]]
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[[Category: Sun J]]
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[[Category: Wang T]]

Current revision

Human epidermal fatty acid-binding protein (FABP5) in complex with the inhibitor BMS-309413

PDB ID 4azm

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