3niq

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{{STRUCTURE_3niq| PDB=3niq | SCENE= }}
 
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===Crystal structure of Pseudomonas aeruginosa guanidinopropionase===
 
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{{ABSTRACT_PUBMED_21600989}}
 
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==About this Structure==
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==Crystal structure of Pseudomonas aeruginosa guanidinopropionase==
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[[3niq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseae Pseae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NIQ OCA].
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<StructureSection load='3niq' size='340' side='right'caption='[[3niq]], [[Resolution|resolution]] 2.07&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3niq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_PAO1 Pseudomonas aeruginosa PAO1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NIQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NIQ FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.07&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3niq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3niq OCA], [https://pdbe.org/3niq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3niq RCSB], [https://www.ebi.ac.uk/pdbsum/3niq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3niq ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/GPUA_PSEAE GPUA_PSEAE] Catalyzes the hydrolysis of 3-guanidinopropanoate to beta-alanine and urea. Possesses low activity against 4-guanidinobutanoate. Has no activity against arginine and agmatine.<ref>PMID:21600989</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Pseudomonas aeruginosa guanidinobutyrase (GbuA) and guanidinopropionase (GpuA) catalyze the hydrolysis of 4-guanidinobutyrate and 3-guanidinopropionate, respectively. They belong to the ureohydrolase superfamily, which includes arginase, agmatinase, proclavaminate amidinohydrolase, and formiminoglutamase. In this study, we have determined the crystal structures of GbuA and GpuA from P. aeruginosa to provide a structural insight into their substrate specificity. Although GbuA and GpuA share a common structural fold of the typical ureohydrolase superfamily, they exhibit significant variations in two active site loops. Mutagenesis of Met161 of GbuA and Tyr157 of GpuA, both of which are located in the active site loop 1 and predicted to be involved in substrate recognition, significantly affected their enzymatic properties, implying their important roles in catalysis.
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==Reference==
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Crystal structures of Pseudomonas aeruginosa guanidinobutyrase and guanidinopropionase, members of the ureohydrolase superfamily.,Lee SJ, Kim DJ, Kim HS, Lee BI, Yoon HJ, Yoon JY, Kim KH, Jang JY, Im HN, An DR, Song JS, Kim HJ, Suh SW J Struct Biol. 2011 May 12. PMID:21600989<ref>PMID:21600989</ref>
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<ref group="xtra">PMID:021600989</ref><references group="xtra"/><references/>
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[[Category: Guanidinopropionase]]
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[Category: Pseae]]
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</div>
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[[Category: An, D.]]
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<div class="pdbe-citations 3niq" style="background-color:#fffaf0;"></div>
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[[Category: Im, H.]]
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== References ==
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[[Category: Jang, J Y.]]
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<references/>
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[[Category: Kim, D J.]]
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__TOC__
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[[Category: Kim, H S.]]
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</StructureSection>
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[[Category: Kim, K H.]]
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[[Category: Large Structures]]
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[[Category: Lee, S J.]]
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[[Category: Pseudomonas aeruginosa PAO1]]
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[[Category: Suh, S W.]]
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[[Category: An D]]
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[[Category: Yoon, H J.]]
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[[Category: Im H]]
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[[Category: Yoon, J Y.]]
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[[Category: Jang JY]]
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[[Category: Gpua]]
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[[Category: Kim DJ]]
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[[Category: Guanidinopropionase]]
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[[Category: Kim HS]]
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[[Category: Hydrolase]]
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[[Category: Kim KH]]
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[[Category: Lee SJ]]
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[[Category: Suh SW]]
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[[Category: Yoon HJ]]
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[[Category: Yoon JY]]

Current revision

Crystal structure of Pseudomonas aeruginosa guanidinopropionase

PDB ID 3niq

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