4bjo

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{{STRUCTURE_4bjo| PDB=4bjo | SCENE= }}
 
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===Nitrate in the active site of PTP1b is a putative mimetic of the transition state===
 
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{{ABSTRACT_PUBMED_24531490}}
 
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==Function==
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==Nitrate in the active site of PTP1b is a putative mimetic of the transition state==
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[[http://www.uniprot.org/uniprot/PTN1_HUMAN PTN1_HUMAN]] Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion.<ref>PMID:21135139</ref> <ref>PMID:22169477</ref>
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<StructureSection load='4bjo' size='340' side='right'caption='[[4bjo]], [[Resolution|resolution]] 2.06&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4bjo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BJO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BJO FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.06&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bjo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bjo OCA], [https://pdbe.org/4bjo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bjo RCSB], [https://www.ebi.ac.uk/pdbsum/4bjo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bjo ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PTN1_HUMAN PTN1_HUMAN] Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion.<ref>PMID:21135139</ref> <ref>PMID:22169477</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The X-ray crystal structure of the complex of protein tyrosine phosphatase 1B with nitrate anion has been determined and modelled quantum-mechanically. Two protomers were present in the structure, one with the mechanistically important WPD loop closed and the other with this loop open. Nitrate was observed bound to each protomer, making close contacts with the S atom of the catalytic cysteine and a tyrosine residue from a crystallographically related protomer.
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==About this Structure==
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Nitrate in the active site of protein tyrosine phosphatase 1B is a putative mimetic of the transition state.,Kenny PW, Newman J, Peat TS Acta Crystallogr D Biol Crystallogr. 2014 Feb;70(Pt 2):565-71. doi:, 10.1107/S1399004713031052. Epub 2014 Jan 31. PMID:24531490<ref>PMID:24531490</ref>
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[[4bjo]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BJO OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<ref group="xtra">PMID:024531490</ref><references group="xtra"/><references/>
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</div>
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[[Category: Protein-tyrosine-phosphatase]]
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<div class="pdbe-citations 4bjo" style="background-color:#fffaf0;"></div>
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[[Category: Kenny, P W.]]
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[[Category: Newman, J.]]
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==See Also==
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[[Category: Peat, T S.]]
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*[[Tyrosine phosphatase 3D structures|Tyrosine phosphatase 3D structures]]
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[[Category: Hydrolase]]
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== References ==
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[[Category: Phosphatase]]
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<references/>
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[[Category: Quantum chemistry]]
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__TOC__
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[[Category: Transition state]]
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Kenny PW]]
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[[Category: Newman J]]
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[[Category: Peat TS]]

Current revision

Nitrate in the active site of PTP1b is a putative mimetic of the transition state

PDB ID 4bjo

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