2mix
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of a novel venom peptide toxin from sample limited terebrid marine snail== | |
| + | <StructureSection load='2mix' size='340' side='right'caption='[[2mix]]' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[2mix]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Terebridae Terebridae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MIX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MIX FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 10 models</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mix FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mix OCA], [https://pdbe.org/2mix PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mix RCSB], [https://www.ebi.ac.uk/pdbsum/2mix PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mix ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/T3A_TERVA T3A_TERVA] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Disulfide-rich peptide toxins found in the secretions of venomous organisms such as snakes, spiders, scorpions, leeches, and marine snails are highly efficient and effective tools for novel therapeutic drug development. Venom peptide toxins have been used extensively to characterize ion channels in the nervous system and platelet aggregation in haemostatic systems. A significant hurdle in characterizing disulfide-rich peptide toxins from venomous animals is obtaining significant quantities needed for sequence and structural analyses. Presented here is a strategy for the structural characterization of venom peptide toxins from sample limited (4 ng) specimens via direct mass spectrometry sequencing, chemical synthesis and NMR structure elucidation. Using this integrated approach, venom peptide Tv1 from Terebra variegata was discovered. Tv1 displays a unique fold not witnessed in prior snail neuropeptides. The novel structural features found for Tv1 suggest that the terebrid pool of peptide toxins may target different neuronal agents with varying specificities compared to previously characterized snail neuropeptides. | ||
| - | + | Sample limited characterization of a novel disulfide-rich venom peptide toxin from terebrid marine snail Terebra variegata.,Anand P, Grigoryan A, Bhuiyan MH, Ueberheide B, Russell V, Quinonez J, Moy P, Chait BT, Poget SF, Holford M PLoS One. 2014 Apr 8;9(4):e94122. doi: 10.1371/journal.pone.0094122. eCollection , 2014. PMID:24713808<ref>PMID:24713808</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| + | </div> | ||
| + | <div class="pdbe-citations 2mix" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Terebridae]] | ||
| + | [[Category: Anand P]] | ||
| + | [[Category: Bhuiyan MH]] | ||
| + | [[Category: Grigoryan A]] | ||
| + | [[Category: Holford M]] | ||
| + | [[Category: Poget SF]] | ||
Current revision
Structure of a novel venom peptide toxin from sample limited terebrid marine snail
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