4cqj

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(New page: '''Unreleased structure''' The entry 4cqj is ON HOLD Authors: McMahon, S.A., Thompson, S., O'Hagan, D., Naismith, J.H. Description: Fluorinase substrate flexibility enables last step a...)
Current revision (12:14, 20 December 2023) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 4cqj is ON HOLD
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==Fluorinase substrate flexibility enables last step aqueous and ambient 18F fluorination of a RGD peptide for positron emission tomography==
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<StructureSection load='4cqj' size='340' side='right'caption='[[4cqj]], [[Resolution|resolution]] 2.44&Aring;' scene=''>
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Authors: McMahon, S.A., Thompson, S., O'Hagan, D., Naismith, J.H.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4cqj]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_cattleya Streptomyces cattleya]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CQJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CQJ FirstGlance]. <br>
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Description: Fluorinase substrate flexibility enables last step aqueous and ambient 18F fluorination of a RGD peptide for positron emission tomography
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.44&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EFA:5-DEOXY-2-ETHYNYL-5-FLUOROADENOSINE'>EFA</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4cqj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cqj OCA], [https://pdbe.org/4cqj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4cqj RCSB], [https://www.ebi.ac.uk/pdbsum/4cqj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4cqj ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/FLA_STRCT FLA_STRCT] Involved in the biosynthesis of fluorometabolites. Catalyzes the formation of a C-F bond by combining S-adenosyl-L-methionine (SAM) and fluoride to generate 5'-fluoro-5'-deoxyadenosine (5'-FDA) and L-methionine. It can also use 2'-deoxyadenosine in place of adenosine as substrate.<ref>PMID:12860396</ref> <ref>PMID:14765200</ref> <ref>PMID:16370017</ref> <ref>PMID:16604208</ref> <ref>PMID:16720268</ref> <ref>PMID:17985882</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Streptomyces cattleya]]
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[[Category: McMahon SA]]
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[[Category: Naismith JH]]
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[[Category: O'Hagan D]]
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[[Category: Thompson S]]

Current revision

Fluorinase substrate flexibility enables last step aqueous and ambient 18F fluorination of a RGD peptide for positron emission tomography

PDB ID 4cqj

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