This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
4oqm
From Proteopedia
(Difference between revisions)
| (5 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of thymidine kinase from herpes simplex virus type 1 in complex with F-ARA-EdU== | |
| + | <StructureSection load='4oqm' size='340' side='right'caption='[[4oqm]], [[Resolution|resolution]] 2.20Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4oqm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_alphaherpesvirus_1_strain_17 Human alphaherpesvirus 1 strain 17]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OQM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4OQM FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FDU:1-(2-DEOXY-2-FLUORO-BETA-D-ARABINOFURANOSYL)-5-ETHYNYLPYRIMIDINE-2,4(1H,3H)-DIONE'>FDU</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4oqm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oqm OCA], [https://pdbe.org/4oqm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4oqm RCSB], [https://www.ebi.ac.uk/pdbsum/4oqm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4oqm ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/KITH_HHV11 KITH_HHV11] In latent infection, may allow the virus to be reactivated and to grow in cells lacking a high concentration of phosphorylated nucleic acid precursors, such as nerve cells that do not replicate their genome (By similarity). | ||
| - | + | ==See Also== | |
| - | + | *[[Thymidine kinase 3D structures|Thymidine kinase 3D structures]] | |
| - | + | __TOC__ | |
| + | </StructureSection> | ||
| + | [[Category: Human alphaherpesvirus 1 strain 17]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Luedtke N]] | ||
| + | [[Category: Neef AB]] | ||
| + | [[Category: Pernot L]] | ||
| + | [[Category: Perozzo R]] | ||
| + | [[Category: Scapozza L]] | ||
| + | [[Category: Westermaier Y]] | ||
Current revision
Crystal structure of thymidine kinase from herpes simplex virus type 1 in complex with F-ARA-EdU
| |||||||||||
