4ov2
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 4ov2 is ON HOLD Authors: Pandaleneni, S., Burgoyne, R., Mayans, O., Lian, L.-Y. Description: Crystal structure of C-terminally truncated Neuronal C...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of C-terminally truncated Neuronal Calcium Sensor (NCS-1) from Rattus norvegicus== | |
| - | + | <StructureSection load='4ov2' size='340' side='right'caption='[[4ov2]], [[Resolution|resolution]] 2.60Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4ov2]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OV2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4OV2 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6Å</td></tr> | |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ov2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ov2 OCA], [https://pdbe.org/4ov2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ov2 RCSB], [https://www.ebi.ac.uk/pdbsum/4ov2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ov2 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/NCS1_RAT NCS1_RAT] Neuronal calcium sensor, regulator of G protein-coupled receptor phosphorylation in a calcium dependent manner. Directly regulates GRK1 (RHOK), but not GRK2 to GRK5. Can substitute for calmodulin. Stimulates PI4KB kinase activity. Involved in long-term synaptic plasticity through its interaction with PICK1. May also play a role in neuron differentiation through inhibition of the activity of N-type voltage-gated calcium channel.<ref>PMID:17502602</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Rattus norvegicus]] | ||
| + | [[Category: Burgoyne R]] | ||
| + | [[Category: Lian L-Y]] | ||
| + | [[Category: Mayans O]] | ||
| + | [[Category: Pandaleneni S]] | ||
Current revision
Crystal structure of C-terminally truncated Neuronal Calcium Sensor (NCS-1) from Rattus norvegicus
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