4ne2

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (16:55, 20 September 2023) (edit) (undo)
 
(4 intermediate revisions not shown.)
Line 1: Line 1:
-
{{STRUCTURE_4ne2| PDB=4ne2 | SCENE= }}
 
-
===Pantothenamide-bound Pantothenate Kinase from Klebsiella pneumoniae===
 
-
{{ABSTRACT_PUBMED_24470271}}
 
-
==About this Structure==
+
==Pantothenamide-bound Pantothenate Kinase from Klebsiella pneumoniae==
-
[[4ne2]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NE2 OCA].
+
<StructureSection load='4ne2' size='340' side='right'caption='[[4ne2]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[4ne2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Klebsiella_pneumoniae_342 Klebsiella pneumoniae 342]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NE2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NE2 FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
 +
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SH2:(R)-N-(3-((2-(BENZO[D][1,3]DIOXOL-5-YL)ETHYL)AMINO)-3-OXOPROPYL)-2,4-DIHYDROXY-3,3-DIMETHYLBUTANAMIDE'>SH2</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ne2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ne2 OCA], [https://pdbe.org/4ne2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ne2 RCSB], [https://www.ebi.ac.uk/pdbsum/4ne2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ne2 ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/COAA_KLEP3 COAA_KLEP3]
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
Pantothenate kinase (PanK) is the rate-limiting enzyme in Coenzyme A biosynthesis, catalyzing the ATP-dependent phosphorylation of pantothenate. We solved the co-crystal structures of PanKs from Staphylococcus aureus (SaPanK) and Klebsiella pneumonia (KpPanK) with N-[2-(1,3-benzodioxol-5-yl)ethyl] pantothenamide (N354-Pan). Two different N354-Pan conformers interact with polar/nonpolar mixed residues in SaPanK and aromatic residues in KpPanK. Additionally, phosphorylated N354-Pan is found at the closed active site of SaPanK but not at the open active site of KpPanK, suggesting an exchange of the phosphorylated product with a new N354-Pan only in KpPanK. Together, pantothenamides conformational flexibility and binding pocket are two key considerations for selective compound design. Proteins 2014. (c) 2014 Wiley Periodicals, Inc.
-
==Reference==
+
Structural characterization of a new N-substituted pantothenamide bound to pantothenate kinases from Klebsiella pneumonia and Staphylococcus aureus.,Hughes SJ, Antoshchenko T, Kim KP, Smil D, Park HW Proteins. 2014 Jan 28. doi: 10.1002/prot.24524. PMID:24470271<ref>PMID:24470271</ref>
-
<ref group="xtra">PMID:024470271</ref><references group="xtra"/><references/>
+
 
-
[[Category: Pantothenate kinase]]
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
[[Category: Antoshchenko, T.]]
+
</div>
-
[[Category: Hughes, S J.]]
+
<div class="pdbe-citations 4ne2" style="background-color:#fffaf0;"></div>
-
[[Category: Kim, K P.]]
+
 
-
[[Category: Park, H W.]]
+
==See Also==
-
[[Category: Smil, D.]]
+
*[[Pantothenate kinase 3D structures|Pantothenate kinase 3D structures]]
-
[[Category: Protein-substrate complex]]
+
== References ==
-
[[Category: Transferase]]
+
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Klebsiella pneumoniae 342]]
 +
[[Category: Large Structures]]
 +
[[Category: Antoshchenko T]]
 +
[[Category: Hughes SJ]]
 +
[[Category: Kim KP]]
 +
[[Category: Park HW]]
 +
[[Category: Smil D]]

Current revision

Pantothenamide-bound Pantothenate Kinase from Klebsiella pneumoniae

PDB ID 4ne2

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4ne2"
Personal tools