401d

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[[Image:401d.gif|left|200px]]<br /><applet load="401d" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="401d, resolution 2.200&Aring;" />
 
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'''STRUCTURE OF A DNA IN LOW SALT CONDITIONS D(GACCGCGGTC)'''<br />
 
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==Overview==
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==STRUCTURE OF A DNA IN LOW SALT CONDITIONS D(GACCGCGGTC)==
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The X-ray crystal structure of the DNA decamer d(GACCGCGGTC), containing half the human papilloma virus E2 binding site, has been solved from two crystals grown at different ionic conditions (50 mM MgCl2and 50 mM spermine or 1.56 mM MgCl2and 1.56 mM spermine). Despite the variation in salt concentration, the two DNA structures are in a very similar, A-type DNA conformation, with helical axes curving towards the major groove. Although the salt concentrations do not effect the helical parameters or hydration to a large degree, there is a change in the overall helical curvature; 18 degrees and 31 degrees for the low and high salt structures, respectively. This curvature appears to be sequence specific and biologically relevant when compared with similar DNA structures, including the E2 binding site of a protein-DNA complex.
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<StructureSection load='401d' size='340' side='right'caption='[[401d]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[401d]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=401D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=401D FirstGlance]. <br>
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401D is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=401D OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=401d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=401d OCA], [https://pdbe.org/401d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=401d RCSB], [https://www.ebi.ac.uk/pdbsum/401d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=401d ProSAT]</span></td></tr>
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==Reference==
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</table>
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X-ray crystal structures of half the human papilloma virus E2 binding site: d(GACCGCGGTC)., Finley JB, Luo M, Nucleic Acids Res. 1998 Dec 15;26(24):5719-27. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9838004 9838004]
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__TOC__
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[[Category: Protein complex]]
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</StructureSection>
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[[Category: Finley, J B.]]
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[[Category: Large Structures]]
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[[Category: Luo, M.]]
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[[Category: Finley JB]]
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[[Category: dna double helix]]
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[[Category: Luo M]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 19:11:52 2008''
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Current revision

STRUCTURE OF A DNA IN LOW SALT CONDITIONS D(GACCGCGGTC)

PDB ID 401d

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