407d

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[[Image:407d.gif|left|200px]]<br /><applet load="407d" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="407d, resolution 2.200&Aring;" />
 
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'''STRUCTURAL BASIS FOR RECOGNITION OF A-T AND T-A BASE PAIRS IN THE MINOR GROOVE OF B-DNA'''<br />
 
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==Overview==
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==STRUCTURAL BASIS FOR RECOGNITION OF A-T AND T-A BASE PAIRS IN THE MINOR GROOVE OF B-DNA==
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Polyamide dimers containing three types of aromatic rings-pyrrole, imidazole, and hydroxypyrrole-afford a small-molecule recognition code that discriminates among all four Watson-Crick base pairs in the minor groove. The crystal structure of a specific polyamide dimer-DNA complex establishes the structural basis for distinguishing T.A from A.T base pairs. Specificity for the T.A base pair is achieved by means of distinct hydrogen bonds between pairs of substituted pyrroles on the ligand and the O2 of thymine and N3 of adenine. In addition, shape-selective recognition of an asymmetric cleft between the thymine-O2 and the adenine-C2 was observed. Although hitherto similarities among the base pairs in the minor groove have been emphasized, the structure illustrates differences that allow specific minor groove recognition.
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<StructureSection load='407d' size='340' side='right'caption='[[407d]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[407d]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=407D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=407D FirstGlance]. <br>
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407D is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ] with <scene name='pdbligand=HP1:'>HP1</scene> and <scene name='pdbligand=TRS:'>TRS</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=407D OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HP1:IMIDAZOLE-PYRROLE-HYDROXYPYRROLE+POLYAMIDE'>HP1</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
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==Reference==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=407d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=407d OCA], [https://pdbe.org/407d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=407d RCSB], [https://www.ebi.ac.uk/pdbsum/407d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=407d ProSAT]</span></td></tr>
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A structural basis for recognition of A.T and T.A base pairs in the minor groove of B-DNA., Kielkopf CL, White S, Szewczyk JW, Turner JM, Baird EE, Dervan PB, Rees DC, Science. 1998 Oct 2;282(5386):111-5. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9756473 9756473]
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</table>
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[[Category: Protein complex]]
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__TOC__
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[[Category: Rees]]
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</StructureSection>
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[[Category: HP1]]
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[[Category: Large Structures]]
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[[Category: TRS]]
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[[Category: Synthetic construct]]
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[[Category: drugs in the dna minor groove]]
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[[Category: Rees DC]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 19:11:57 2008''
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Current revision

STRUCTURAL BASIS FOR RECOGNITION OF A-T AND T-A BASE PAIRS IN THE MINOR GROOVE OF B-DNA

PDB ID 407d

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