4i1t

{{STRUCTURE_4i1t| PDB=4i1t | SCENE= }}

===Crystal structure of the cap-snatching endonuclease from Pichinde virus===

==Function==

[[http://www.uniprot.org/uniprot/Q915A5_PIARV Q915A5_PIARV]] RNA-dependent RNA polymerase which is responsible for replication and transcription of the viral RNA genome. During transcription, synthesizes 4 subgenomic RNAs, and assures their capping by a cap-snatching mechanism, in which cellular capped pre-mRNA are used to generate primers for viral transcription. The 3'-end of subgenomic mRNAs molecules are heterogeneous and not polyadenylated. The replicase function is to direct synthesis of antigenomic and genomic RNA which are encapsidated and non capped. As a consequence of the use of the same enzyme for both transcription and replication, these mechanisms need to be well coordinated. These processes may be regulated by proteins N and Z in a dose-dependent manner (By similarity).[PIRNR:PIRNR000836]

==About this Structure==

[[4i1t]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I1T OCA].

[[Category: RNA-directed RNA polymerase]]

[[Category: Arenavirus]]

[[Category: Cap-snatching]]

[[Category: Cap-snatching rna endonuclease]]

[[Category: Endonuclease]]

[[Category: Viral transcription]]