Factor XIII
From Proteopedia
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| - | + | <StructureSection load='1ggt' size='350' side='right' caption='Human Factor XIII dimer (PDB entry [[1ggt]])' scene='Factor_XIII/Cv/1'> | |
| - | + | == Function == | |
| - | [[Factor XIII]] (FXIII) belongs to the blood coagulation system and crosslinks fibrin resulting in an insoluble clot. FXIII is activated by thrombin which cleaves it and releases an activation peptide. | + | [[Factor XIII]] (FXIII) belongs to the blood coagulation system and crosslinks fibrin resulting in an insoluble clot. FXIII is activated by thrombin which cleaves it and releases an activation peptide<ref>PMID:17842715</ref>. |
| - | + | == Disease == | |
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| + | FXIII deficiency causes internal bleeding. | ||
| + | </StructureSection> | ||
== 3D Structures of Factor XIII == | == 3D Structures of Factor XIII == | ||
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[[1ggt]] – hFXIII - human <br /> | [[1ggt]] – hFXIII - human <br /> | ||
| + | [[8cmt]], [[8cmu]] - hFXIII – Cryo EM<br /> | ||
[[1ex0]] – hFXIII zymogen (mutant)<br /> | [[1ex0]] – hFXIII zymogen (mutant)<br /> | ||
[[1fie]] – hFXIII subunit A<br /> | [[1fie]] – hFXIII subunit A<br /> | ||
[[1f13]] - hFXIII zymogen subunit A dimer<br /> | [[1f13]] - hFXIII zymogen subunit A dimer<br /> | ||
[[4kty]] - hFXIII subunit A + peptide-like ligand<br /> | [[4kty]] - hFXIII subunit A + peptide-like ligand<br /> | ||
| + | [[5mhl]], [[5mhm]], [[5mhn]], [[5mho]] - hFXIII subunit A (mutant) + peptide inhibitor<br /> | ||
[[1ggy]], [[1qrk]], [[1ggu]], [[1evu]] – hFXIII + ion<br /> | [[1ggy]], [[1qrk]], [[1ggu]], [[1evu]] – hFXIII + ion<br /> | ||
| - | [[1de7]] – | + | [[1de7]] – hFXIII activation peptide + α-thrombin<br /> |
| + | == References == | ||
| + | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Current revision
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3D Structures of Factor XIII
Updated on 08-June-2025
1ggt – hFXIII - human
8cmt, 8cmu - hFXIII – Cryo EM
1ex0 – hFXIII zymogen (mutant)
1fie – hFXIII subunit A
1f13 - hFXIII zymogen subunit A dimer
4kty - hFXIII subunit A + peptide-like ligand
5mhl, 5mhm, 5mhn, 5mho - hFXIII subunit A (mutant) + peptide inhibitor
1ggy, 1qrk, 1ggu, 1evu – hFXIII + ion
1de7 – hFXIII activation peptide + α-thrombin
References
- ↑ Laki K, Lorand L. On the Solubility of Fibrin Clots. Science. 1948 Sep 10;108(2802):280. PMID:17842715 doi:http://dx.doi.org/10.1126/science.108.2802.280
