4po6
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 4po6 is ON HOLD until Paper Publication Authors: Wallweber, H.J.A., Lupardus, P.J. Description: Crystal structure of the human TYK2 FERM and SH2 do...) |
|||
| (5 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of the human TYK2 FERM and SH2 domains with an IFNAR1 intracellular peptide== | |
| + | <StructureSection load='4po6' size='340' side='right'caption='[[4po6]], [[Resolution|resolution]] 1.99Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4po6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PO6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PO6 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.99Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4po6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4po6 OCA], [https://pdbe.org/4po6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4po6 RCSB], [https://www.ebi.ac.uk/pdbsum/4po6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4po6 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/TYK2_HUMAN TYK2_HUMAN] Mendelian susceptibility to mycobacterial diseases;Autosomal recessive hyper IgE syndrome. Defects in TYK2 are the cause of protein-tyrosine kinase 2 deficiency (TYK2 deficiency) [MIM:[https://omim.org/entry/611521 611521]; also known as autosomal recessive hyper-IgE syndrome (HIES) with atypical mycobacteriosis. TYK2 deficiency consists of a primary immunodeficiency characterized by recurrent skin abscesses, pneumonia, and highly elevated serum IgE. | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/TYK2_HUMAN TYK2_HUMAN] Probably involved in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain.<ref>PMID:7526154</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Interferon receptor 3D structures|Interferon receptor 3D structures]] | |
| - | + | *[[Tyrosine kinase 3D structures|Tyrosine kinase 3D structures]] | |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Lupardus PJ]] | ||
| + | [[Category: Wallweber HJA]] | ||
Current revision
Crystal structure of the human TYK2 FERM and SH2 domains with an IFNAR1 intracellular peptide
| |||||||||||
