4pon
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 4pon is ON HOLD until Paper Publication Authors: Park, S.C., Song, W.S., Yoon, S.I. Description: The crystal structure of a bacterial protein) |
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| - | '''Unreleased structure''' | ||
| - | The | + | ==The crystal structure of a putative SAM-dependent methyltransferase, YtqB, from Bacillus subtilis== |
| + | <StructureSection load='4pon' size='340' side='right'caption='[[4pon]], [[Resolution|resolution]] 1.90Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4pon]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis_subsp._spizizenii_str._W23 Bacillus subtilis subsp. spizizenii str. W23]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PON OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PON FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9Å</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4pon FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pon OCA], [https://pdbe.org/4pon PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4pon RCSB], [https://www.ebi.ac.uk/pdbsum/4pon PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4pon ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/E0TY72_BACSH E0TY72_BACSH] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | S-adenosyl-l-methionine (SAM)-dependent methyltransferases (MTases) methylate diverse biological molecules using a SAM cofactor. The ytqB gene of Bacillus subtilis encodes a putative MTase and its biological function has never been characterized. To reveal the structural features and the cofactor binding mode of YtqB, we have determined the crystal structures of YtqB alone and in complex with its cofactor, SAM, at 1.9A and 2.2A resolutions, respectively. YtqB folds into a beta-sheet sandwiched by two alpha-helical layers, and assembles into a dimeric form. Each YtqB monomer contains one SAM binding site, which shapes SAM into a slightly curved conformation and exposes the reactive methyl group of SAM potentially to a substrate. Our comparative structural analysis of YtqB and its homologues indicates that YtqB is a SAM-dependent class I MTase, and provides insights into the substrate binding site of YtqB. | ||
| - | + | Structural analysis of a putative SAM-dependent methyltransferase, YtqB, from Bacillus subtilis.,Park SC, Song WS, Yoon SI Biochem Biophys Res Commun. 2014 Mar 14. pii: S0006-291X(14)00460-4. doi:, 10.1016/j.bbrc.2014.03.026. PMID:24637210<ref>PMID:24637210</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| + | </div> | ||
| + | <div class="pdbe-citations 4pon" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Bacillus subtilis subsp. spizizenii str. W23]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Park SC]] | ||
| + | [[Category: Song WS]] | ||
| + | [[Category: Yoon SI]] | ||
Current revision
The crystal structure of a putative SAM-dependent methyltransferase, YtqB, from Bacillus subtilis
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