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4nat

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{{STRUCTURE_4nat| PDB=4nat | SCENE= }}
 
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===Inhibitors of 4-Phosphopanthetheine Adenylyltransferase===
 
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{{ABSTRACT_PUBMED_24041904}}
 
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==Function==
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==Inhibitors of 4-Phosphopanthetheine Adenylyltransferase==
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[[http://www.uniprot.org/uniprot/COAD_STAAW COAD_STAAW]] Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity).
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<StructureSection load='4nat' size='340' side='right'caption='[[4nat]], [[Resolution|resolution]] 1.72&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[4nat]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_MW2 Staphylococcus aureus subsp. aureus MW2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NAT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NAT FirstGlance]. <br>
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[[4nat]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NAT OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.72&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2W5:(1R,2R)-N-(3,4-DICHLOROBENZYL)-2-(4,6-DIMETHOXYPYRIMIDIN-2-YL)CYCLOHEXANECARBOXAMIDE'>2W5</scene>, <scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene></td></tr>
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==Reference==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4nat FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nat OCA], [https://pdbe.org/4nat PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4nat RCSB], [https://www.ebi.ac.uk/pdbsum/4nat PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4nat ProSAT]</span></td></tr>
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<ref group="xtra">PMID:024041904</ref><references group="xtra"/><references/>
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</table>
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[[Category: Pantetheine-phosphate adenylyltransferase]]
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== Function ==
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[[Category: Lahiri, S D.]]
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[https://www.uniprot.org/uniprot/COAD_STAAW COAD_STAAW] Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity).
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[[Category: Coabc]]
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__TOC__
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[[Category: Coad]]
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</StructureSection>
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[[Category: Cytosolic]]
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[[Category: Large Structures]]
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[[Category: Panthetheine]]
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[[Category: Staphylococcus aureus subsp. aureus MW2]]
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[[Category: Phosphopanthetheine adenylyltransferase]]
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[[Category: Lahiri SD]]
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[[Category: Transferase-transferase inhibitor complex]]
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Current revision

Inhibitors of 4-Phosphopanthetheine Adenylyltransferase

PDB ID 4nat

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