4nat
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| - | {{STRUCTURE_4nat| PDB=4nat | SCENE= }} | ||
| - | ===Inhibitors of 4-Phosphopanthetheine Adenylyltransferase=== | ||
| - | {{ABSTRACT_PUBMED_24041904}} | ||
| - | == | + | ==Inhibitors of 4-Phosphopanthetheine Adenylyltransferase== |
| - | [[ | + | <StructureSection load='4nat' size='340' side='right'caption='[[4nat]], [[Resolution|resolution]] 1.72Å' scene=''> |
| - | + | == Structural highlights == | |
| - | == | + | <table><tr><td colspan='2'>[[4nat]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_MW2 Staphylococcus aureus subsp. aureus MW2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NAT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NAT FirstGlance]. <br> |
| - | [[4nat]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NAT OCA]. | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.72Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2W5:(1R,2R)-N-(3,4-DICHLOROBENZYL)-2-(4,6-DIMETHOXYPYRIMIDIN-2-YL)CYCLOHEXANECARBOXAMIDE'>2W5</scene>, <scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene></td></tr> | |
| - | == | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4nat FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nat OCA], [https://pdbe.org/4nat PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4nat RCSB], [https://www.ebi.ac.uk/pdbsum/4nat PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4nat ProSAT]</span></td></tr> |
| - | < | + | </table> |
| - | [[ | + | == Function == |
| - | [ | + | [https://www.uniprot.org/uniprot/COAD_STAAW COAD_STAAW] Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity). |
| - | [ | + | __TOC__ |
| - | + | </StructureSection> | |
| - | [ | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Staphylococcus aureus subsp. aureus MW2]] |
| - | [[Category: | + | [[Category: Lahiri SD]] |
| - | [[Category: | + | |
Current revision
Inhibitors of 4-Phosphopanthetheine Adenylyltransferase
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